Streptolysin O concentration and activity is central to in vivo phenotype and disease outcome in Group A Streptococcus infection

Streptolysin O concentration and activity is central to in vivo phenotype and disease outcome in Group A Streptococcus infection

Group A Streptoccocus (GAS) is among the many most numerous of all human pathogens, accountable for a variety of medical manifestations, from delicate superficial infections akin to pharyngitis to severe invasive infections akin to necrotising fasciitis and sepsis.
The drivers of those completely different illness phenotypes aren’t recognized. The GAS cholesterol-dependent cytolysin, Streptolysin O (SLO), has properly established cell and tissue harmful exercise. We investigated the position of SLO in figuring out illness final result in vivo, by utilizing two completely different medical lineages; the not too long ago emerged hypervirulent outbreak emm kind 32.2 strains, which end in sepsis, and the emm kind 1.Zero strains which trigger septic arthritis.
Utilizing clinically related in vivo mouse fashions of sepsis and a novel septic arthritis mannequin, we discovered that the quantity and exercise of SLO was important in figuring out the course of an infection. The emm kind 32.2 pressure produced giant portions of extremely haemolytic SLO that resulted in speedy growth of sepsis.
Against this, the lowered focus and decrease haemolytic exercise of emm kind 1.Zero SLO led to translocation of micro organism from blood to joints. Importantly, sepsis related strains that have been attenuated by deletion or inhibition of SLO, then additionally translocated to the joint, confirming the important thing position of SLO in figuring out an infection area of interest.
Our findings show that SLO is vital to in vivo phenotype and illness final result. Cautious consideration needs to be given to novel remedy or vaccination methods that focus on SLO. While neutralising SLO exercise might cut back extreme invasive illness, it has the potential to advertise continual inflammatory circumstances akin to septic arthritis.

A longitudinal sampling research of transcriptomic and epigenetic profiles in sufferers with thrombocytopenia syndrome’

Extreme fever with thrombocytopenia syndrome (SFTS) is a novel tick-borne infectious illness attributable to a brand new kind of SFTS virus (SFTSV). Right here, a longitudinal sampling research is performed to discover the variations in transcript ranges after SFTSV an infection, and to characterize the transcriptomic and epigenetic profiles of hospitalized sufferers.
The outcomes reveal important modifications within the mRNA expression of sure genes from onset to restoration. Furthermore, m6A-seq reveals that sure genes associated with immune regulation could also be regulated by m6A.
Moreover the routine checks akin to platelet counts, serum ALT and AST ranges testing, distinct modifications in myocardial enzymes, coagulation perform, and irritation are properly correlated with the medical knowledge and sequencing knowledge, suggesting that medical practitioners ought to monitor the above indicators to trace illness development and information personalised therapy.
On this research, the transcript modifications and RNA modification might lend a contemporary perspective to our understanding of the SFTSV and play a major position within the discovery of medication for efficient therapy of this illness.

Optimising classification of Parkinson’s illness primarily based on motor, olfactory, neuropsychiatric and sleep options

Olfactory loss, motor impairment, anxiousness/despair, and REM-sleep behaviour dysfunction (RBD) are prodromal Parkinson’s illness (PD) options. PD threat prediction fashions sometimes dichotomize take a look at outcomes and apply probability ratios (LRs) to scores above and under cut-offs. We examine whether or not LRs for particular take a look at values might improve classification between PD and controls.
PD affected person knowledge on odor (UPSIT), attainable RBD (RBD Screening Questionnaire), and anxiousness/despair (LADS) have been taken from the Monitoring Parkinson’s research (n = 1046). For motor impairment (BRAIN take a look at) in PD circumstances, revealed knowledge have been supplemented (n = 87). Management knowledge (HADS for anxiousness/despair) have been taken from the PREDICT-PD pilot research (n = 1314).
UPSIT, RBDSQ, and anxiousness/despair knowledge have been analysed utilizing logistic regression to find out which gadgets have been related to PD. Gaussian distributions have been fitted to BRAIN take a look at scores. LRs have been calculated from logistic regression fashions or rating distributions. False-positive charges (FPRs) for specified detection charges (DRs) have been calculated.
Sixteen odours have been related to PD; LRs for this set ranged from 0.005 to 5511. Six RBDSQ and 7 anxiousness/despair questions have been related to PD; LRs ranged from 0.35 to 69 and from 0.002 to 402, respectively. BRAIN take a look at LRs ranged from 0.16 to 1311. For a 70% DR, the FPR was 2.4% for the 16 odours, 4.6% for anxiousness/despair, 16.0% for the BRAIN take a look at, and 20.0% for the RBDSQ.
Particular choices of (prodromal) PD marker options reasonably than dichotomized marker take a look at outcomes optimize PD classification. Such optimized classification fashions might enhance the power of algorithms to detect prodromal PD; nevertheless, potential research are wanted to analyze their worth for PD-prediction fashions.

Sleep issues in ache sufferers coming into tertiary ache care: the position of pain-related anxiousness, medicine use, self-reported ailments, and sleep issues

Continual ache and sleep issues regularly co-occur. Ache itself disturbs sleep, however different elements can also contribute to sleep issues in ache sufferers. This cross-sectional research of 473 sufferers (69.9% feminine, imply age 47 years) coming into tertiary ache administration in contrast usually sleeping ache sufferers with these having recurring sleep issues to find out the connection between ache and sleep.
Teams have been in contrast for ache and ache aetiology, pain-related anxiousness, childhood adversities, use of sleep and ache medicines, self-reported ailments, and sleep issues. Additional, the affiliation of pain-related anxiousness (cognitive anxiousness, escape/avoidance, worry, and physiological anxiousness) with extra disturbing sleep issues was investigated in the entire cohort.
The primary outcomes have been that these with sleep issues extra typically reported a number of well being circumstances than these sleeping usually (despair 31.6% vs 5.0%; angina pectoris 6.5% vs 0.0%; bronchial asthma 19.6% vs 1.7%; low again issues 55.1% vs 23.3%; joint illness apart from rheumatoid arthritis 32.3% vs 18.3%).
Accumulations of 5 or extra childhood adversities have been extra typically current in these with sleep issues. Stressed legs signs have been extra frequent in these with sleep issues than these sleeping usually (33.2% vs 11.7%). Sufferers having sleep issues reported extra use of sleep and ache medicines than these sleeping usually. Findings about pain-related anxiousness recommend physiological reactions as important elements for elevated sleep disturbances. These elements have to be addressed within the administration of the comorbidity of ache and sleep issues and analysis to grasp mechanisms in these is sorely wanted.

Regulation and Position of αE Integrin and Intestine Homing Integrins in Migration and Retention of Intestinal Lymphocytes throughout Inflammatory Bowel Illness

Concentrating on interactions between α4β7 integrin and endothelial adhesion molecule MAdCAM-1 to inhibit lymphocyte migration to the gastrointestinal tract is an efficient remedy in inflammatory bowel illness (IBD). Following lymphocyte entry into the mucosa, a subset of those cells expresses αEβ7 integrin, which is expressed on proinflammatory lymphocytes, to extend cell retention.
The elements governing lymphocyte migration into the intestinal mucosa and αE integrin expression in wholesome topics and IBD sufferers stay incompletely understood. We evaluated modifications in elements concerned in lymphocyte migration and differentiation inside tissues.
Each ileal and colonic tissue from lively IBD sufferers confirmed upregulation of ICAM-1, VCAM-1, and MAdCAM-1 on the gene and protein ranges in contrast with wholesome topics and/or inactive IBD sufferers. β1 and β7 integrin expression on circulating lymphocytes was comparable throughout teams.
TGF-β1 therapy induced expression of αE on each β7+ and β7 T cells, suggesting that cells coming into the mucosa independently of MAdCAM-1/α4β7 can grow to be αEβ7+ ITGAE gene polymorphisms didn’t alter protein induction following TGF-β1 stimulation.
Elevated phospho-SMAD3, which is immediately downstream of TGF-β, and elevated TGF-β-responsive gene expression have been noticed within the colonic mucosa of IBD sufferers. Lastly, in vitro stimulation experiments confirmed that baseline β7 expression had little impact on cytokine, chemokine, transcription issue, and effector molecule gene expression in αE+ and αE T cells.

ARVCF - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector

TL314639 5 µg/vial Ask for price

Arvcf ORF Vector (Rat) (pORF)

ORF063700 1.0 ug DNA
EUR 607.2

ARVCF ORF Vector (Human) (pORF)

ORF015835 1.0 ug DNA
EUR 486

Arvcf ORF Vector (Mouse) (pORF)

ORF039132 1.0 ug DNA
EUR 607.2

ARVCF Protein Vector (Rat) (pPM-C-HA)

PV254800 500 ng
EUR 1399.2

ARVCF Protein Vector (Rat) (pPB-C-His)

PV254798 500 ng
EUR 1399.2

ARVCF Protein Vector (Rat) (pPB-N-His)

PV254799 500 ng
EUR 1399.2

ARVCF Protein Vector (Rat) (pPM-C-His)

PV254801 500 ng
EUR 1399.2

ARVCF Protein Vector (Human) (pPM-C-HA)

PV063339 500 ng
EUR 973.2

ARVCF Protein Vector (Mouse) (pPM-C-HA)

PV156528 500 ng
EUR 1278

ARVCF Protein Vector (Human) (pPB-C-His)

PV063337 500 ng
EUR 973.2

ARVCF Protein Vector (Human) (pPB-N-His)

PV063338 500 ng
EUR 973.2

ARVCF Protein Vector (Human) (pPM-C-His)

PV063340 500 ng
EUR 973.2

ARVCF Protein Vector (Mouse) (pPB-C-His)

PV156526 500 ng
EUR 1278

ARVCF Protein Vector (Mouse) (pPB-N-His)

PV156527 500 ng
EUR 1278

ARVCF Protein Vector (Mouse) (pPM-C-His)

PV156529 500 ng
EUR 1278

ARVCF Protein Vector (Human) (pPB-His-MBP)

PV324102 500 ng
EUR 973.2

ARVCF Protein Vector (Human) (pPB-His-GST)

PV324103 500 ng
EUR 973.2

Arvcf - Rat shRNA lentiviral particles (4 unique 29mer target-specific shRNA, 1 scramble control), 0.5 ml each, >10^7 TU/ml.

TL708611V 500 ul each Ask for price

Arvcf - Mouse shRNA lentiviral particles (4 unique 29mer target-specific shRNA, 1 scramble control), 0.5 ml each, >10^7 TU/ml.

TL500142V 500 ul each Ask for price

ARVCF - Human shRNA lentiviral particles (4 unique 29mer target-specific shRNA, 1 scramble control), 0.5 ml each, >10^7 TU/ml.

TL314639V 500 ul each Ask for price

ARVCF Protein Vector (Human) (pPM-N-D-C-HA)

PV324104 500 ng
EUR 1216.8

ARVCF Protein Vector (Human) (pPM-N-D-C-His)

PV324105 500 ng
EUR 1216.8

Arvcf sgRNA CRISPR Lentivector set (Rat)

K7275001 3 x 1.0 ug
EUR 406.8

ARVCF sgRNA CRISPR Lentivector set (Human)

K0129701 3 x 1.0 ug
EUR 406.8

Arvcf sgRNA CRISPR Lentivector set (Mouse)

K4629501 3 x 1.0 ug
EUR 406.8

Arvcf - Rat, 4 unique 29mer shRNA constructs in retroviral untagged vector

TR708611 5 µg/vial Ask for price

Arvcf sgRNA CRISPR Lentivector (Rat) (Target 1)

K7275002 1.0 ug DNA
EUR 184.8

Arvcf sgRNA CRISPR Lentivector (Rat) (Target 2)

K7275003 1.0 ug DNA
EUR 184.8

Arvcf sgRNA CRISPR Lentivector (Rat) (Target 3)

K7275004 1.0 ug DNA
EUR 184.8

ARVD1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV719087 1.0 ug DNA Ask for price

ARVD1 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)

LV719091 1.0 ug DNA Ask for price

ARVD3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV719093 1.0 ug DNA Ask for price

ARVD3 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)

LV719097 1.0 ug DNA Ask for price

ARVD4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV719099 1.0 ug DNA Ask for price

ARVD4 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)

LV719103 1.0 ug DNA Ask for price

ARVD5 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV719105 1.0 ug DNA Ask for price

ARVD5 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)

LV719109 1.0 ug DNA Ask for price

Arvcf - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector

TR500142 5 µg/vial Ask for price

ARVCF - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector

TR314639 5 µg/vial Ask for price

ARVCF siRNA

20-abx908260
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

ARVCF siRNA

20-abx908261
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

ARVCF sgRNA CRISPR Lentivector (Human) (Target 1)

K0129702 1.0 ug DNA
EUR 184.8

ARVCF sgRNA CRISPR Lentivector (Human) (Target 2)

K0129703 1.0 ug DNA
EUR 184.8

ARVCF sgRNA CRISPR Lentivector (Human) (Target 3)

K0129704 1.0 ug DNA
EUR 184.8

Arvcf sgRNA CRISPR Lentivector (Mouse) (Target 1)

K4629502 1.0 ug DNA
EUR 184.8

Arvcf sgRNA CRISPR Lentivector (Mouse) (Target 2)

K4629503 1.0 ug DNA
EUR 184.8

Arvcf sgRNA CRISPR Lentivector (Mouse) (Target 3)

K4629504 1.0 ug DNA
EUR 184.8

ARVD1 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV719092 1.0 ug DNA Ask for price

ARVD3 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV719098 1.0 ug DNA Ask for price

ARVD4 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV719104 1.0 ug DNA Ask for price

ARVD5 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV719110 1.0 ug DNA Ask for price

ARVCF Antibody

E40PV468 50ul
EUR 395
Description: Available in various conjugation types.

CD Lentiviral Vector

LV678 10 μg
EUR 950

Arv1 - Rat, 4 unique 29mer shRNA constructs in lentiviral GFP vector

TL704784 5 µg/vial Ask for price

ARV1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector

TL306559 5 µg/vial Ask for price

Arv1 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector

TL504228 5 µg/vial Ask for price

ARVCF Rabbit pAb

A19304 50μL
EUR 262.15

ARVCF siRNA (Human)

MBS8202258-15nmol 15nmol
EUR 405

ARVCF siRNA (Human)

MBS8202258-30nmol 30nmol
EUR 565

ARVCF siRNA (Human)

MBS8202258-5x30nmol 5x30nmol
EUR 2450

ARVCF siRNA (Mouse)

MBS8215797-15nmol 15nmol
EUR 405

ARVCF siRNA (Mouse)

MBS8215797-30nmol 30nmol
EUR 565

ARVCF siRNA (Mouse)

MBS8215797-5x30nmol 5x30nmol
EUR 2450

dCas9-KRAB Lentiviral Vector

K203 10 ug
EUR 165
Description: N/A

Cas9 Nickase Lentiviral Vector

K005 10 ug
EUR 135
Description: N/A

ARVD1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV719088 1.0 ug DNA Ask for price

ARVD3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV719094 1.0 ug DNA Ask for price

ARVD4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV719100 1.0 ug DNA Ask for price

ARVD5 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV719106 1.0 ug DNA Ask for price

Cas9 Nuclease Lentiviral Vector

K002 10 ug
EUR 135
Description: N/A

dCas9-TET1CD Lentiviral Vector

K096 10 µg, Titer: N/A
EUR 395
Description: N/A

dCas9-DNMT3A Lentiviral Vector

K091 10 µg, Titer: N/A
EUR 395
Description: N/A

ARVD1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV719089 1.0 ug DNA Ask for price

ARVD1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV719090 1.0 ug DNA Ask for price

ARVD3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV719095 1.0 ug DNA Ask for price

ARVD3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV719096 1.0 ug DNA Ask for price

ARVD4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV719101 1.0 ug DNA Ask for price

ARVD4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV719102 1.0 ug DNA Ask for price

ARVD5 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV719107 1.0 ug DNA Ask for price

ARVD5 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV719108 1.0 ug DNA Ask for price

ARVCF Oxidase antibody

20R-2590 100 uL
EUR 599
Description: Guinea Pig polyclonal ARVCF Oxidase antibody

ARVCF Oxidase antibody

MBS834889-01mL 0.1mL
EUR 975

ARVCF Oxidase antibody

MBS834889-5x01mL 5x0.1mL
EUR 4235

Arvcf sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)

K7275005 3 x 1.0 ug
EUR 451.2

Lenti ORF clone of Arvcf (mGFP-tagged) - Mouse armadillo repeat gene deleted in velo-cardio-facial syndrome (Arvcf)

MR211321L4 10 µg Ask for price

Green Kit. Baculovirus GFP vector.

K20 1 Kit
EUR 695
Description: Protein expression

Lenti ORF particles, ARVCF (mGFP-tagged) - Human armadillo repeat gene deleted in velocardiofacial syndrome (ARVCF), 200ul, >10^7 TU/mL

RC222598L2V 200 µl Ask for price

Lenti ORF particles, ARVCF (mGFP-tagged) - Human armadillo repeat gene deleted in velocardiofacial syndrome (ARVCF), 200ul, >10^7 TU/mL

RC222598L4V 200 µl Ask for price

ARVCF Polyclonal Antibody

MBS9234455-01mL 0.1mL
EUR 415

ARVCF Polyclonal Antibody

MBS9234455-5x01mL 5x0.1mL
EUR 1841

ARVCF Polyclonal Antibody

BS65730 50ul
EUR 208
Description: Rabbit

ARVCF sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

K0129705 3 x 1.0 ug
EUR 451.2

Arvcf sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)

K4629505 3 x 1.0 ug
EUR 451.2

ProGreen. Baculovirus GFP marker vector.

A1 25 ul
EUR 420
Description: Protein expression

Lenti ORF particles, ARVCF (Myc-DDK tagged) - Human armadillo repeat gene deleted in velocardiofacial syndrome (ARVCF), 200ul, >10^7 TU/mL

RC222598L1V 200 µl Ask for price

Lenti ORF particles, ARVCF (Myc-DDK tagged) - Human armadillo repeat gene deleted in velocardiofacial syndrome (ARVCF), 200ul, >10^7 TU/mL

RC222598L3V 200 µl Ask for price

pVL1393. General baculovirus plasmid vector.

B1 50 ul
EUR 340
Description: Protein expression

Lenti ORF particles, Arvcf (GFP-tagged) - Mouse armadillo repeat gene deleted in velo-cardio-facial syndrome (Arvcf), 200ul, >10^7 TU/mL

MR211321L4V 200 µl Ask for price

Cas9 Double Mutant Lentiviral Vector

K012 10 ug
EUR 395
Description: N/A

Lenti ORF clone of Arvcf (Myc-DDK-tagged) - Mouse armadillo repeat gene deleted in velo-cardio-facial syndrome (Arvcf)

MR211321L3 10 µg Ask for price

Human ARVCF ELISA KIT

ELI-34376h 96tests
EUR 696

Mouse Arvcf ELISA KIT

ELI-49351m 96tests
EUR 736

Mouse Arvcf ELISA Kit

EF014236 96tests
EUR 566

Human ARVCF ELISA KIT

EF004632 96tests
EUR 566

Lenti ORF particles, Arvcf (GFP-tagged ORF) - Rat armadillo repeat gene deleted in velo-cardio-facial syndrome (Arvcf), 200ul, >10^7 TU/mL

RR207946L4V 200 µl Ask for price

Arvcf sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1)

K7275006 1.0 ug DNA
EUR 200.4

Arvcf sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2)

K7275007 1.0 ug DNA
EUR 200.4

Arvcf sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3)

K7275008 1.0 ug DNA
EUR 200.4

Lenti ORF particles, Arvcf (Myc-DDK-tagged) - Mouse armadillo repeat gene deleted in velo-cardio-facial syndrome (Arvcf), 200ul, >10^7 TU/mL

MR211321L3V 200 µl Ask for price

Lenti ORF clone of Arvcf (mGFP-tagged ORF) - Rat armadillo repeat gene deleted in velo-cardio-facial syndrome (Arvcf), (10 ug)

RR207946L4 10 µg Ask for price

ARVP6125 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector

TL315355 5 µg/vial Ask for price

Mouse ARVCF shRNA Plasmid

20-abx969243
  • Ask for price
  • Ask for price
  • 150 µg
  • 300 µg

Human ARVCF shRNA Plasmid

20-abx950307
  • Ask for price
  • Ask for price
  • 150 µg
  • 300 µg

ARVCF sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)

K0129706 1.0 ug DNA
EUR 200.4

ARVCF sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)

K0129707 1.0 ug DNA
EUR 200.4

ARVCF sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)

K0129708 1.0 ug DNA
EUR 200.4

Arvcf sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)

K4629506 1.0 ug DNA
EUR 200.4

Arvcf sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)

K4629507 1.0 ug DNA
EUR 200.4

Arvcf sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)

K4629508 1.0 ug DNA
EUR 200.4

ARVCF (untagged)-Human armadillo repeat gene deleted in velocardiofacial syndrome (ARVCF)

SC315001 10 µg Ask for price

Luciferase-mCherry Lentiviral Vector (CMV)

LV010138 1.0 μg
EUR 230

Human ARVCF Protein Lysate

MBS137594-002mg 0.02mg
EUR 545

Human ARVCF Protein Lysate

MBS137594-5x002mg 5x0.02mg
EUR 2225

Lenti ORF particles, Arvcf (Myc-DDK-tagged ORF) - Rat armadillo repeat gene deleted in velo-cardio-facial syndrome (Arvcf), 200ul, >10^7 TU/mL

RR207946L3V 200 µl Ask for price

ESR1 Lentiviral Vector (Human) (pLenti-II)

LV010008 1.0 ug DNA
EUR 379.2

Lenti ORF clone of Arvcf (Myc-DDK-tagged ORF) - Rat armadillo repeat gene deleted in velo-cardio-facial syndrome (Arvcf), (10 ug)

RR207946L3 10 µg Ask for price

ARVCF Peptide - middle region

MBS3247212-01mg 0.1mg
EUR 180

ARVCF Peptide - middle region

MBS3247212-5x01mg 5x0.1mg
EUR 730

ARVCF (NM_001670) Human Over-expression Lysate

LS000421 100ug
EUR 960
Description: Transient overexpression lysate of armadillo repeat gene deletes in velocardiofacial syndrome (ARVCF)

ARVCF Antibody - middle region

MBS3222544-01mL 0.1mL
EUR 455

ARVCF Antibody - middle region

MBS3222544-5x01mL 5x0.1mL
EUR 1995

ProEasy. Vector for easy construction of recombinant baculoviruses.

A10S 25 ul
EUR 695
Description: Protein expression

pLenti-GFP Lentiviral Control Vector

LTV-400 100 µL
EUR 500

pLenti-GFP Lentiviral Control Vector

MBS168202-01mL 0.1mL
EUR 660

pLenti-GFP Lentiviral Control Vector

MBS168202-5x01mL 5x0.1mL
EUR 2795

ARVCF (GFP-tagged) - Human armadillo repeat gene deleted in velocardiofacial syndrome (ARVCF)

RG222598 10 µg Ask for price

ARVCF Rabbit Polyclonal Antibody

54612 100ul
EUR 439

ARVCF Rabbit Polyclonal Antibody

MBS9467735-005mL 0.05mL
EUR 300

ARVCF Rabbit Polyclonal Antibody

MBS9467735-01mL 0.1mL
EUR 390

ARVCF Rabbit Polyclonal Antibody

MBS9467735-5x01mL 5x0.1mL
EUR 1610

pAcAB3. Baculovirus plasmid vector for expression of up to 3 proteins.

B2 50 ul
EUR 420
Description: Protein expression

pSMPUW-Neo Lentiviral Expression Vector

VPK-213 10 µg
EUR 505

pLenti-MCS Lentiviral Expression Vector

LV000 10 µg
EUR 416.5

pSMPUW-Neo Lentiviral Expression Vector

MBS169522-001mg 0.01mg
EUR 665

pSMPUW-Neo Lentiviral Expression Vector

MBS169522-5x001mg 5x0.01mg
EUR 2825

pAB-bee. Baculovirus plasmid vector for secreted and transmembrane proteins.

B3 50 ul
EUR 495
Description: Protein expression

pSMPUW-Puro Lentiviral Expression Vector

VPK-212 10 µg
EUR 505

pSMPUW-Puro Lentiviral Expression Vector

MBS169521-001mg 0.01mg
EUR 665

pSMPUW-Puro Lentiviral Expression Vector

MBS169521-5x001mg 5x0.01mg
EUR 2825

pSMPUW-Hygro Lentiviral Expression Vector

VPK-214 10 µg
EUR 505

pSMPUW-MNDnLacZ Lentiviral Control Vector

LTV-402 10 µg
EUR 741.6
Description: Use this control vector to co-transfect along with lentivirus packaging vectors to make a recombinant control lentivirus.

pSMPUW-Hygro Lentiviral Expression Vector

MBS169523-001mg 0.01mg
EUR 665

pSMPUW-Hygro Lentiviral Expression Vector

MBS169523-5x001mg 5x0.01mg
EUR 2825

ARVCF (Myc-DDK-tagged)-Human armadillo repeat gene deleted in velocardiofacial syndrome (ARVCF)

RC222598 10 µg Ask for price

Human ARVCF knockout cell line

ABC-KH1041 1 vial Ask for price
Description: Human ARVCF knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

ProFold-PDI. Baculovirus chaperone vector for expression of cysteine-rich proteins.

A7 25 ul
EUR 830
Description: Protein expression

Human ARVCF knockdown cell line

ABC-KD1041 1 vial Ask for price
Description: Human ARVCF knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human ARVCF Protein Lysate 20ug

IHUARVCFPLLY20UG each
EUR 361
Description: Human ARVCF Protein Lysate 20ug

TH Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV699655 1.0 ug DNA
EUR 818.4

TH Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV699659 1.0 ug DNA
EUR 818.4

SI Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV694363 1.0 ug DNA
EUR 3415.2

SI Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV694367 1.0 ug DNA
EUR 3415.2

MB Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV694681 1.0 ug DNA
EUR 616.8

MB Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV694685 1.0 ug DNA
EUR 616.8

T Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV639319 1.0 ug DNA
EUR 818.4

T Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV639323 1.0 ug DNA
EUR 818.4

F7 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV666001 1.0 ug DNA
EUR 818.4

F7 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV666005 1.0 ug DNA
EUR 818.4

FH Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV666085 1.0 ug DNA
EUR 818.4

FH Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV666089 1.0 ug DNA
EUR 818.4

F9 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV667969 1.0 ug DNA
EUR 818.4

F9 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV667973 1.0 ug DNA
EUR 818.4

C6 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV673381 1.0 ug DNA
EUR 1626

C6 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV673385 1.0 ug DNA
EUR 1626

KL Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV673531 1.0 ug DNA
EUR 1626

KL Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV673535 1.0 ug DNA
EUR 1626
These findings recommend cell migration to the intestine mucosa could also be altered in IBD and α4β7, and α4β7+ T cells might upregulate αEβ7 in response to TGF-β as soon as throughout the intestine mucosa.

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