Streptolysin O concentration and activity is central to in vivo phenotype and disease outcome in Group A Streptococcus infection

Streptolysin O concentration and activity is central to in vivo phenotype and disease outcome in Group A Streptococcus infection

Group A Streptoccocus (GAS) is among the many most numerous of all human pathogens, accountable for a variety of medical manifestations, from delicate superficial infections akin to pharyngitis to severe invasive infections akin to necrotising fasciitis and sepsis. The drivers of those completely different illness phenotypes aren’t recognized. The GAS cholesterol-dependent cytolysin, Streptolysin O (SLO),…

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