Homozygous missense WIPI2 variants cause a congenital disorder of autophagy with neurodevelopmental impairments of variable clinical severity and disease course

WIPI2 is a member of the human WIPI protein household (seven-bladed b-propeller proteins binding phosphatidylinositols, PROPPINs), which play a pivotal position in autophagy and has been implicated within the pathogenesis of a number of neurological situations.

The homozygous WIPI2 variant c.745G>A; p.(Val249Met) (NM_015610.4) has not too long ago been related to a neurodevelopmental dysfunction in a single household. Utilizing exome sequencing and Sanger segregation evaluation, right here, two novel homozygous WIPI2 variants [c.551T>G; p.(Val184Gly) and c.724C>T; p.(Arg242Trp) (NM_015610.4)] had been recognized in 4 people of two consanguineous households.

Moreover, follow-up medical information had been sought from the beforehand reported household. Three non-ambulant affected siblings of the primary household harbouring the p.(Val184Gly) missense variant introduced with microcephaly, profound world developmental delay/mental incapacity, refractory childish/childhood-onset epilepsy, progressive tetraplegia with joint contractures and dyskinesia.

In distinction, the proband of the second household carrying the p.(Arg242Trp) missense variant, just like the initially reported WIPI2 instances, introduced with a milder phenotype, encompassing reasonable mental incapacity, speech and visible impairment, autistic options, and an ataxic gait.

Mind MR imaging in 5 sufferers confirmed distinguished white matter involvement with a world discount in quantity, posterior corpus callosum hypoplasia, irregular dentate nuclei and hypoplasia of the inferior cerebellar vermis. To research the practical influence of those novel WIPI2 variants, we overexpressed each in WIPI2-knockout HEK293A cells.

Compared to wildtype, expression of the Val166Gly WIPI2b mutant resulted in a poor rescue of LC3 lipidation whereas Arg224Trp mutant elevated LC3 lipidation, in keeping with the beforehand reported Val231Met variant. These findings assist a dysregulation of the early steps of the autophagy pathway. Collectively, our findings present proof that biallelic WIPI2 variants trigger a neurodevelopmental dysfunction of variable severity and illness course. Our report expands the medical spectrum and establishes WIPI2-associated dysfunction as a congenital problems of autophagy.

Scientific Efficacy and Security of Human Mesenchymal Stem Cell Remedy for Degenerative Disc Illness: A Systematic Overview and Meta-Evaluation of Randomized Managed Trials

Degenerative disc illness (DDD) may cause extreme low again ache, which can have a severe detrimental influence on the flexibility to carry out each day duties or actions. For the previous few years, mesenchymal stem cell (MSC) transplantation has emerged as a promising technique for the therapy of DDD.

Nevertheless, the medical efficacy of MSC within the therapy of DDD nonetheless lacks medical proof and is controversial. We performed a meta-analysis with randomized managed trials (RCTs) to judge the medical efficacy and security of MSC transplantation in sufferers with DDD. We searched main databases utilizing phrases from the database’s inception by March 2021.

The Cochrane bias danger evaluation device was used to evaluate high quality. The evaluation confirmed that MSC remedy might lower visible analog scale (VAS) scores (SMD = -0.50, 95%CI = -0.68 ~ -0.33, P < 0.00001) and Oswestry Incapacity Index (ODI) scores (SMD = -0.27, 95%CI = -0.44 ~ -0.09, P = 0.003). The outcomes with subgroup evaluation confirmed that MSC remedy might lower VAS scores in Three months (P = 0.001), 6 months (P = 0.01), 12 months (P = 0.02), and ≥24 months (P = 0.002) and ODI scores in ≥24 months (P = 0.006).

Pooled evaluation confirmed that MSC remedy has the next ratio of sufferers at most thresholds however notably on the MIC (minimally vital change) (P = 0.0002) and CSC (clinically vital change) (P = 0.0002) in VAS and MIC (P = 0.0005) and CSC (P = 0.001) ache responders in ODI. Hostile occasions (AE) of treatment-emergent opposed occasions (TEAE), again ache, arthralgia, and muscle spasms weren’t statistically vital between the 2 teams.

Nevertheless, our additional statistical evaluation confirmed that MSC remedy might induce AE of TEAE associated to review therapy (OR = 3.05, 95%CI = 1.11 ~ 8.40, P = 0.03). In conclusion, this examine pooled the primary outcomes and confirmed that MSC remedy might considerably lower VAS and ODI scores in sufferers with DDD. Distinctly, the findings of this meta-analysis counsel a novel therapeutic technique for sufferers with persistent low again ache (LBP) and lumbar dysfunction by DDD.

Complete-Blood Mitochondrial DNA Copies Are Related With the Prognosis of Acute Respiratory Misery Syndrome After Sepsis

Acute respiratory misery syndrome (ARDS) is an inflammatory means of the lungs that develops primarily in response to pulmonary or systemic sepsis, leading to a disproportionate demise toll in intensive care items (ICUs). Given its position as a vital activator of the inflammatory and innate immune responses, earlier research have reported that a rise of circulating cell-free mitochondrial DNA (mtDNA) is a biomarker for deadly end result within the ICU.

Right here we analyzed the affiliation of whole-blood mtDNA (wb-mtDNA) copies with 28-day survival from sepsis and sepsis-associated ARDS. We analyzed mtDNA information from 687 peripheral whole-blood samples inside 24 h of sepsis prognosis from unrelated Spanish sufferers with sepsis (264 with ARDS) included within the GEN-SEP examine.

The wb-mtDNA copies had been obtained from the array intensities of chosen probes, with 100% id with mtDNA and with the biggest variety of mismatches with the nuclear sequences, and normalized throughout the individual-probe intensities. We used Cox regression fashions for testing the affiliation with 28-day survival.

We noticed that wb-mtDNA copies had been considerably related to 28-day survival in ARDS sufferers (hazard ratio = 3.65, 95% confidence interval = 1.39-9.59, p = 0.009) however not in non-ARDS sufferers. Our findings assist that wb-mtDNA copies at sepsis prognosis might be thought of an early prognostic biomarker in sepsis-associated ARDS sufferers. Future research might be wanted to judge the mechanistic hyperlinks of this commentary with the pathogenesis of ARDS.

Identification of Key Candidate Genes and Chemical Perturbagens in Diabetic Kidney Illness Utilizing Built-in Bioinformatics Evaluation

Globally, almost 40 p.c of all diabetic sufferers develop severe diabetic kidney illness (DKD). The identification of the potential early-stage biomarkers and elucidation of their underlying molecular mechanisms in DKD are required. On this examine, we carried out built-in bioinformatics evaluation on the expression profiles GSE111154, GSE30528 and GSE30529 related to early diabetic nephropathy (EDN), glomerular DKD (GDKD) and tubular DKD (TDKD), respectively.

A complete of 1,241, 318 and 280 differentially expressed genes (DEGs) had been recognized for GSE30258, GSE30529, and GSE111154 respectively. Subsequently, 280 upregulated and 27 downregulated DEGs shared between the three GSE datasets had been recognized.

Additional evaluation of the gene expression ranges performed on the hub genes revealed SPARC (Secreted Protein Acidic And Cysteine Wealthy), POSTN (periostin), LUM (Lumican), KNG1 (Kininogen 1), FN1 (Fibronectin 1), VCAN (Versican) and PTPRO (Protein Tyrosine Phosphatase Receptor Kind O) having potential roles in DKD development.

FN1, LUM and VCAN had been recognized as upregulated genes for GDKD whereas the downregulation of PTPRO was related to all three illnesses. Each POSTN and SPARC had been recognized because the overexpressed putative biomarkers whereas KNG1 was discovered as downregulated in TDKD.

Williams-Beuren Syndrome Chromosomal Region 22 Protein (WBSCR22) Antibody
abx031474-400ul	Abbexa	400 ul	EUR 627.6

Williams-Beuren Syndrome Chromosomal Region 22 Protein (WBSCR22) Antibody
abx031474-80l	Abbexa	80 µl	EUR 343.2

Williams-Beuren Syndrome Chromosomal Region 27 Protein (WBSCR27) Antibody
abx025778-400ul	Abbexa	400 ul	EUR 627.6

Williams-Beuren Syndrome Chromosomal Region 27 Protein (WBSCR27) Antibody
abx025778-80l	Abbexa	80 µl	EUR 343.2

Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) Antibody
20-abx171618	Abbexa	EUR 1111.20 EUR 560.40	1 mg 200 ug

Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) Antibody
20-abx129047	Abbexa	EUR 543.60 EUR 159.60 EUR 1579.20 EUR 744.00 EUR 410.40	100 ug 10 ug 1 mg 200 ug 50 ug

Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) Antibody (Biotin)
20-abx274484	Abbexa	EUR 577.20 EUR 292.80 EUR 1713.60 EUR 811.20 EUR 427.20	100 ug 10 ug 1 mg 200 ug 50 ug

Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) Polyclonal Antibody (Human)
4-PAL307Hu01	Cloud-Clone	EUR 314.40 EUR 3296.40 EUR 814.80 EUR 397.20 EUR 264.00	100ul 10ml 1ml 200ul 20ul

Description: A Rabbit polyclonal antibody against Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1)

Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) Polyclonal Antibody (Human), PE
4-PAL307Hu01-PE	Cloud-Clone	EUR 376.80 EUR 3478.80 EUR 976.80 EUR 476.40 EUR 243.60	100ul 10ml 1ml 200ul 20ul

Description: A Rabbit polyclonal antibody against Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1). This antibody is labeled with PE.

Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) Polyclonal Antibody (Human), APC
4-PAL307Hu01-APC	Cloud-Clone	EUR 441.60 EUR 4318.80 EUR 1191.60 EUR 566.40 EUR 274.80	100ul 10ml 1ml 200ul 20ul

Description: A Rabbit polyclonal antibody against Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1). This antibody is labeled with APC.

Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) Polyclonal Antibody (Human), Cy3
4-PAL307Hu01-Cy3	Cloud-Clone	EUR 538.80 EUR 5708.40 EUR 1539.60 EUR 705.60 EUR 316.80	100ul 10ml 1ml 200ul 20ul

Description: A Rabbit polyclonal antibody against Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1). This antibody is labeled with Cy3.

Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) Polyclonal Antibody (Human), FITC
4-PAL307Hu01-FITC	Cloud-Clone	EUR 376.80 EUR 3478.80 EUR 976.80 EUR 476.40 EUR 243.60	100ul 10ml 1ml 200ul 20ul

Description: A Rabbit polyclonal antibody against Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1). This antibody is labeled with FITC.

Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) Polyclonal Antibody (Human), HRP
4-PAL307Hu01-HRP	Cloud-Clone	EUR 402.00 EUR 3762.00 EUR 1052.40 EUR 511.20 EUR 258.00	100ul 10ml 1ml 200ul 20ul

Description: A Rabbit polyclonal antibody against Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1). This antibody is labeled with HRP.

Recombinant Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1)
4-RPL307Hu01	Cloud-Clone	EUR 636.10 EUR 294.00 EUR 2055.36 EUR 765.12 EUR 1410.24 EUR 501.60 EUR 4958.40	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg

Description: Recombinant Human Cat Eye Syndrome Chromosome Region, Candidate 1 expressed in: E.coli

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) Protein
20-abx167165	Abbexa	EUR 878.40 EUR 343.20 EUR 2766.00 EUR 1062.00 EUR 627.60	100 ug 10 ug 1 mg 200 ug 50 ug

Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) Polyclonal Antibody (Human), APC-Cy7
4-PAL307Hu01-APC-Cy7	Cloud-Clone	EUR 739.20 EUR 8493.60 EUR 2240.40 EUR 988.80 EUR 405.60	100ul 10ml 1ml 200ul 20ul

Description: A Rabbit polyclonal antibody against Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1). This antibody is labeled with APC-Cy7.

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) CLIA Kit
20-abx190184	Abbexa	EUR 9493.20 EUR 5058.00 EUR 1167.60	10 × 96 tests 5 × 96 tests 96 tests

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1)CLIA Kit
SCL307Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 6777.36

Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) in serum, plasma and other biological fluids.

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1)CLIA Kit
SCL307Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 663.31

Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) in serum, plasma and other biological fluids.

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1)CLIA Kit
SCL307Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 896.16

Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) in serum, plasma and other biological fluids.

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1)CLIA Kit
SCL307Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 3672.72

Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) in serum, plasma and other biological fluids.

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) CLIA Kit
4-SCL307Hu	Cloud-Clone	EUR 6837.60 EUR 3673.20 EUR 896.40	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells

Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1)Serum, plasma and other biological fluids

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit
abx055599-96tests	Abbexa	96 tests	EUR 904.8

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit
abx250398-96tests	Abbexa	96 tests	EUR 904.8

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit
20-abx151029	Abbexa	EUR 8853.60 EUR 4719.60 EUR 1093.20	10 × 96 tests 5 × 96 tests 96 tests

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit
DLR-CECR1-Hu-48T	DL Develop	48T	EUR 664.8

Description: A sandwich quantitative ELISA assay kit for detection of Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) in samples from serum, plasma or other biological fluids.

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit
DLR-CECR1-Hu-96T	DL Develop	96T	EUR 870

Description: A sandwich quantitative ELISA assay kit for detection of Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) in samples from serum, plasma or other biological fluids.

Human Cat Eye Syndrome Chromosome Region, Candidate 1(CECR1) ELISA Kit
QY-E02201	Qayee Biotechnology	96T	EUR 433.2

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit
RDR-CECR1-Hu-48Tests	Reddot Biotech	48 Tests	EUR 706.8

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit
RDR-CECR1-Hu-96Tests	Reddot Biotech	96 Tests	EUR 984

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit
RD-CECR1-Hu-48Tests	Reddot Biotech	48 Tests	EUR 675.6

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit
RD-CECR1-Hu-96Tests	Reddot Biotech	96 Tests	EUR 939.6

Human Cat Eye Syndrome Chromosome Region, Candidate 1 ELISA Kit (CECR1)
RK01087	Abclonal	96 Tests	EUR 625.2

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit
SEL307Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 6227.58

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) in serum, plasma and other biological fluids.

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit
SEL307Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 618.04

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) in serum, plasma and other biological fluids.

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit
SEL307Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 831.48

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) in serum, plasma and other biological fluids.

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit
SEL307Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 3381.66

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) in serum, plasma and other biological fluids.

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit
4-SEL307Hu	Cloud-Clone	EUR 6288.00 EUR 3322.80 EUR 831.60	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells

Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) in samples from Serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species.

Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) Polyclonal Antibody (Human), Biotinylated
4-PAL307Hu01-Biotin	Cloud-Clone	EUR 393.60 EUR 3236.40 EUR 943.20 EUR 484.80 EUR 271.20	100ul 10ml 1ml 200ul 20ul

Description: A Rabbit polyclonal antibody against Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1). This antibody is labeled with Biotin.

ELISA kit for Human CECR1 (Cat Eye Syndrome Chromosome Region, Candidate 1)
ELK6564	ELK Biotech	1 plate of 96 wells	EUR 518.4

Description: A sandwich ELISA kit for detection of Cat Eye Syndrome Chromosome Region, Candidate 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

ELISA kit for Human CECR1 (Cat Eye Syndrome Chromosome Region, Candidate 1)
E-EL-H5495	Elabscience Biotech	1 plate of 96 wells	EUR 640.8

Description: A sandwich ELISA kit for quantitative measurement of Human CECR1 (Cat Eye Syndrome Chromosome Region, Candidate 1) in samples from Serum, Plasma, Cell supernatant

CECR1 Cat Eye Syndrome Chromosome Region Candidate 1 Human Recombinant Protein
PROTQ9NZK5	BosterBio	Regular: 10ug	EUR 380.4
Description: CECR1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 490 amino acids (30-511a.a.) and having a molecular mass of 56.9kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa).;CECR1 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

CPX Chromosome Region, Candidate 1 (CPXCR1) Antibody
abx231948-100ug	Abbexa	100 ug	EUR 610.8

CPX Chromosome Region, Candidate 1 (CPXCR1) Antibody
20-abx318624	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

CPX Chromosome Region, Candidate 1 (CPXCR1) Antibody
abx145283-100ug	Abbexa	100 ug	EUR 469.2

CPX Chromosome Region, Candidate 1 (CPXCR1) Antibody
20-abx148870	Abbexa	EUR 510.00 EUR 410.40	100 ug 50 ug

CPX Chromosome Region, Candidate 1 (CPXCR1) Antibody (HRP)
20-abx308950	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

CPX Chromosome Region, Candidate 1 (CPXCR1) Antibody (FITC)
20-abx308951	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

CPX Chromosome Region, Candidate 1 (CPXCR1) Antibody (Biotin)
20-abx308952	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Chromosome Region Maintenance 1 Protein Homolog (CRM1) Antibody
abx231984-100ug	Abbexa	100 ug	EUR 577.2

Amyotrophic Lateral Sclerosis 2 Chromosome Region 12 (ALS2CR12) Antibody
20-abx338368	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Amyotrophic Lateral Sclerosis 2 Chromosome Region 12 (ALS2CR12) Antibody (HRP)
20-abx334692	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Amyotrophic Lateral Sclerosis 2 Chromosome Region 12 (ALS2CR12) Antibody (FITC)
20-abx334693	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Amyotrophic Lateral Sclerosis 2 Chromosome Region 12 (ALS2CR12) Antibody (Biotin)
20-abx334694	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

DSS-AHC Critical Region On The X Chromosome Protein 1 (DAX1) Antibody
20-abx142103	Abbexa	EUR 444.00 EUR 727.20 EUR 376.80	100 ul 200 ul 50 ul

DSS-AHC Critical Region On The X Chromosome Protein 1 (DAX1) Antibody
abx031637-400ul	Abbexa	400 ul	EUR 627.6

DSS-AHC Critical Region On The X Chromosome Protein 1 (DAX1) Antibody
abx031637-80l	Abbexa	80 µl	EUR 343.2

Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1
PR27224	Neuromics	2 ug	EUR 229.2

Human CPX Chromosome Region, Candidate 1 (CPXCR1) ELISA Kit
abx384735-96tests	Abbexa	96 tests	EUR 1093.2

Mouse CPX Chromosome Region, Candidate 1 (CPXCR1) ELISA Kit
abx388923-96tests	Abbexa	96 tests	EUR 1093.2

Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 Protein
20-abx263361	Abbexa	EUR 1930.80 EUR 393.60 EUR 276.00	100 ug 10 ug 2 µg

Human Non Imprinted In Prader Willi/Angelman Syndrome Region Protein 1 (NIPA1) ELISA Kit
SEJ961Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 5677.8

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Non Imprinted In Prader Willi/Angelman Syndrome Region Protein 1 (NIPA1) in Tissue homogenates, cell lysates and other biological fluids.

Human Non Imprinted In Prader Willi/Angelman Syndrome Region Protein 1 (NIPA1) ELISA Kit
SEJ961Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 572.76

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Non Imprinted In Prader Willi/Angelman Syndrome Region Protein 1 (NIPA1) in Tissue homogenates, cell lysates and other biological fluids.

Human Non Imprinted In Prader Willi/Angelman Syndrome Region Protein 1 (NIPA1) ELISA Kit
SEJ961Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 766.8

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Non Imprinted In Prader Willi/Angelman Syndrome Region Protein 1 (NIPA1) in Tissue homogenates, cell lysates and other biological fluids.

Human Non Imprinted In Prader Willi/Angelman Syndrome Region Protein 1 (NIPA1) ELISA Kit
SEJ961Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 3090.6

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Non Imprinted In Prader Willi/Angelman Syndrome Region Protein 1 (NIPA1) in Tissue homogenates, cell lysates and other biological fluids.

Human Non Imprinted In Prader Willi/Angelman Syndrome Region Protein 1 (NIPA1) ELISA Kit
4-SEJ961Hu	Cloud-Clone	EUR 5738.40 EUR 3031.20 EUR 768.00	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells

Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Non Imprinted In Prader Willi/Angelman Syndrome Region Protein 1 (NIPA1) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

DiGeorge Syndrome Critical Region 6 (DGCR6) Antibody
abx034439-400ul	Abbexa	400 ul	EUR 627.6

DiGeorge Syndrome Critical Region 6 (DGCR6) Antibody
abx034439-80l	Abbexa	80 µl	EUR 343.2

DiGeorge Syndrome Critical Region 14 (DGCR14) Antibody
abx027696-400ul	Abbexa	400 ul	EUR 627.6

DiGeorge Syndrome Critical Region 14 (DGCR14) Antibody
abx027696-80l	Abbexa	80 µl	EUR 343.2

ELISA kit for Human NIPA1 (Non Imprinted In Prader Willi/Angelman Syndrome Region Protein 1)
ELK5358	ELK Biotech	1 plate of 96 wells	EUR 518.4

Description: A sandwich ELISA kit for detection of Non Imprinted In Prader Willi/Angelman Syndrome Region Protein 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Down Syndrome Critical Region Protein 1 (DSCR1) Antibody
abx025110-400ul	Abbexa	400 ul	EUR 627.6

Down Syndrome Critical Region Protein 1 (DSCR1) Antibody
abx025110-80l	Abbexa	80 µl	EUR 343.2

Down Syndrome Critical Region Protein 1 (DSCR1) Antibody
abx025111-400ul	Abbexa	400 ul	EUR 627.6

Down Syndrome Critical Region Protein 1 (DSCR1) Antibody
abx025111-80l	Abbexa	80 µl	EUR 343.2

Down Syndrome Critical Region Protein 2 (DSCR2) Antibody
abx430430-200ul	Abbexa	200 ul	EUR 460.8

Down Syndrome Critical Region Protein 4 (DSCR4) Antibody
20-abx303669	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Down Syndrome Critical Region Protein 9 (DSCR9) Antibody
20-abx301178	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Down Syndrome Critical Region Protein 1 (DSCR1) Antibody
20-abx009324	Abbexa	EUR 360.00 EUR 526.80 EUR 226.80	100 ul 200 ul 30 ul

Down Syndrome Critical Region Protein 3 (DSCR3) Antibody
abx032797-400ul	Abbexa	400 ul	EUR 627.6

Down Syndrome Critical Region Protein 3 (DSCR3) Antibody
abx032797-80l	Abbexa	80 µl	EUR 343.2

DiGeorge Syndrome Critical Region Gene 2 (DGCR2) Antibody
abx232350-100ug	Abbexa	100 ug	EUR 610.8

DiGeorge Syndrome Critical Region Gene 8 (DGCR8) Antibody
abx232351-100ug	Abbexa	100 ug	EUR 577.2

DiGeorge Syndrome Critical Region Gene 8 (DGCR8) Antibody
abx232352-100ug	Abbexa	100 ug	EUR 661.2

DiGeorge Syndrome Critical Region Gene 8 (DGCR8) Antibody
abx232353-100ug	Abbexa	100 ug	EUR 610.8

DiGeorge Syndrome Critical Region Gene 8 (DGCR8) Antibody
abx037565-100ug	Abbexa	100 ug	EUR 469.2

DiGeorge Syndrome Critical Region Gene 8 (DGCR8) Antibody
abx037930-100ug	Abbexa	100 ug	EUR 469.2

DiGeorge Syndrome Critical Region Gene 8 (DGCR8) Antibody
20-abx004627	Abbexa	EUR 594.00 EUR 427.20	100 ul 50 ul

DiGeorge Syndrome Critical Region Gene 8 (DGCR8) Antibody
abx430470-200ul	Abbexa	200 ul	EUR 343.2

DiGeorge Syndrome Critical Region Gene 2 (DGCR2) Antibody
20-abx112067	Abbexa	EUR 878.40 EUR 477.60	150 ul 50 ul

DiGeorge Syndrome Critical Region Gene 8 (DGCR8) Antibody
20-abx112069	Abbexa	EUR 878.40 EUR 477.60	150 ul 50 ul

DiGeorge Syndrome Critical Region Gene 8 (DGCR8) Antibody
20-abx125324	Abbexa	EUR 594.00 EUR 844.80 EUR 427.20	100 ul 200 ul 50 ul

DiGeorge Syndrome Critical Region Gene 2 (DGCR2) Antibody
abx122722-100ug	Abbexa	100 ug	EUR 469.2

DiGeorge Syndrome Critical Region Gene 8 (DGCR8) Antibody
abx149799-100ug	Abbexa	100 ug	EUR 526.8

DiGeorge Syndrome Critical Region Gene 8 (DGCR8) Antibody
abx034165-400ul	Abbexa	400 ul	EUR 627.6

DiGeorge Syndrome Critical Region Gene 8 (DGCR8) Antibody
abx034165-80l	Abbexa	80 µl	EUR 343.2

DiGeorge Syndrome Critical Region Gene 2 (DGCR2) Antibody
abx034378-400ul	Abbexa	400 ul	EUR 627.6

DiGeorge Syndrome Critical Region Gene 2 (DGCR2) Antibody
abx034378-80l	Abbexa	80 µl	EUR 343.2

Cat Eye Syndrome Critical Region Protein 2 (CECR2) Antibody
20-abx136053	Abbexa	EUR 493.20 EUR 710.40 EUR 218.40 EUR 376.80	100 ul 200 ul 20 ul 50 ul

Cat Eye Syndrome Critical Region Protein 5 (CECR5) Antibody
abx033997-400ul	Abbexa	400 ul	EUR 627.6

Cat Eye Syndrome Critical Region Protein 5 (CECR5) Antibody
abx033997-80l	Abbexa	80 µl	EUR 343.2

Cat Eye Syndrome Critical Region Protein 6 (CECR6) Antibody
abx029845-400ul	Abbexa	400 ul	EUR 627.6

Cat Eye Syndrome Critical Region Protein 6 (CECR6) Antibody
abx029845-80l	Abbexa	80 µl	EUR 343.2

Cat Eye Syndrome Critical Region Protein 2 (CECR2) Antibody
abx432490-200ul	Abbexa	200 ul	EUR 343.2

Williams' Medium E
CM063-050	GenDepot	500ml	EUR 109.2

Williams' Medium E
CM063-300	GenDepot	6x500ml	EUR 319.2

Williams' Medium E
CM063-310	GenDepot	10x500ml	EUR 375.6

Williams' Medium E
CM063-320	GenDepot	20x500ml	EUR 724.8

Williams' Medium E
CM063-350	GenDepot	50x500ml	EUR 1170

Putative BPES Syndrome Breakpoint Region Protein (BPESC1) Antibody
20-abx311773	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Digeorge Syndrome Critical Region Gene 6-Like (DGCR6L) Antibody
20-abx112068	Abbexa	EUR 878.40 EUR 477.60	150 ul 50 ul

ASPSCR1 Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 Human Recombinant Protein
PROTQ9BZE9	BosterBio	Regular: 10ug	EUR 380.4
Description: ASPSCR1 Human Recombinant produced in E. coli is a single polypeptide chain containing 576 amino acids (1-553) and having a molecular mass of 62.6kDa. ASPSCR1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

MKS1 Antibody / Meckel syndrome type 1 protein (N-Terminal Region)
F54181-0.05ML	NSJ Bioreagents	0.05 ml	EUR 140.25
Description: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology.

MKS1 Antibody / Meckel syndrome type 1 protein (N-Terminal Region)
F54181-0.2ML	NSJ Bioreagents	0.2 ml	EUR 322.15
Description: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology.

MKS1 Antibody / Meckel syndrome type 1 protein (N-Terminal Region)
F54182-0.05ML	NSJ Bioreagents	0.05 ml	EUR 140.25
Description: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology.

MKS1 Antibody / Meckel syndrome type 1 protein (N-Terminal Region)
F54182-0.2ML	NSJ Bioreagents	0.2 ml	EUR 322.15
Description: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology.

DiGeorge Syndrome Critical Region 6-Like Protein (DGCR6L) Antibody
20-abx318669	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Chromosome 16 Open Reading Frame 14 (MCRIP2) Antibody
20-abx111660	Abbexa	EUR 878.40 EUR 477.60	150 ul 50 ul

Chromosome 16 Open Reading Frame 45 (C16orf45) Antibody
abx231034-100ug	Abbexa	100 ug	EUR 610.8

Chromosome 16 Open Reading Frame 70 (C16orf70) Antibody
abx231036-100ug	Abbexa	100 ug	EUR 577.2

Chromosome 16 Open Reading Frame 72 (C16orf72) Antibody
abx231037-100ug	Abbexa	100 ug	EUR 610.8

Chromosome 16 Open Reading Frame 70 (C16ORF70) Antibody
20-abx111661	Abbexa	EUR 878.40 EUR 477.60	150 ul 50 ul

Chromosome 16 Open Reading Frame 78 (C16ORF78) Antibody
20-abx301590	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Chromosome 16 Open Reading Frame 62 (C16ORF62) Antibody
20-abx302517	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Chromosome 16 Open Reading Frame 87 (C16ORF87) Antibody
20-abx308129	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Anti-Phospho-DiGeorge Syndrome Critical Region 8 DGCR8 (Ser377) Antibody
P00475	BosterBio	100ul	EUR 477.6
Description: Rabbit Polyclonal Phospho-DiGeorge Syndrome Critical Region 8 DGCR8 (Ser377) Antibody. Validated in WB and tested in Human, Mouse.

Chromosome 16 Open Reading Frame 62 (C16ORF62) Antibody (HRP)
20-abx316352	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Chromosome 16 Open Reading Frame 87 (C16ORF87) Antibody (HRP)
20-abx308130	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Chromosome 16 Open Reading Frame 78 (C16ORF78) Antibody (HRP)
20-abx309975	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Chromosome 16 Open Reading Frame 62 (C16ORF62) Antibody (FITC)
20-abx316353	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Chromosome 16 Open Reading Frame 87 (C16ORF87) Antibody (FITC)
20-abx308131	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Chromosome 16 Open Reading Frame 78 (C16ORF78) Antibody (FITC)
20-abx309976	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

DiGeorge Syndrome Critical Region Gene 6 Protein
20-abx261930	Abbexa	EUR 5388.00 EUR 393.60 EUR 276.00	1 mg 20 ug 5 ug

Chromosome 16 Open Reading Frame 62 (C16ORF62) Antibody (Biotin)
20-abx316354	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Chromosome 16 Open Reading Frame 87 (C16ORF87) Antibody (Biotin)
20-abx308132	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Chromosome 16 Open Reading Frame 78 (C16ORF78) Antibody (Biotin)
20-abx309977	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 16 Protein (ALS2CR16) Antibody
20-abx148159	Abbexa	EUR 510.00 EUR 410.40	100 ug 50 ug

DiGeorge Syndrome Critical Region Gene 6-Like Protein
20-abx263350	Abbexa	EUR 1930.80 EUR 393.60 EUR 276.00	100 ug 10 ug 2 µg

Recombinant (E.Coli) Human Down Syndrome Critical Region 1
RP-785	Alpha Diagnostics	5 ug	EUR 196.8

RCC1 Antibody / Regulator of Chromosome Condensation
RQ5918	NSJ Bioreagents	100 ug	EUR 356.15
Description: CHC1, also named as RCC1, SNHG3-RCC1, promotes the exchange of ran-bound gdp by gtp. It is involved in the regulation of onset of chromosome condensation in the S-phase. Phosphorylation of RCC1 on serines located in or near its nuclear localization signal activates RCC1 to generate RanGTP on mitotic chromosomes, which is required for spindle assembly and chromosome segregation. This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human RCC1. The geneID has updated as 1104 recently.

Rat anti chromosome antibody ELISA kit
E02A2057-192T	BlueGene	192 tests	EUR 1524

Description: A sandwich ELISA for quantitative measurement of Rat anti chromosome antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat anti chromosome antibody ELISA kit
E02A2057-48	BlueGene	1 plate of 48 wells	EUR 624

Description: A sandwich ELISA for quantitative measurement of Rat anti chromosome antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat anti chromosome antibody ELISA kit
E02A2057-96	BlueGene	1 plate of 96 wells	EUR 822

Description: A sandwich ELISA for quantitative measurement of Rat anti chromosome antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog anti chromosome antibody ELISA kit
E08A2057-192T	BlueGene	192 tests	EUR 1524

Description: A sandwich ELISA for quantitative measurement of Canine anti chromosome antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Moreover, we additionally recognized two medication, particularly pidorubicine, a topoisomerase inhibitor (LINCS ID- BRD-Okay04548931) and Polo-like kinase inhibitor (LINCS ID- BRD-Okay41652870) having the validated position in reversing the differential gene expression patterns noticed within the three GSE datasets used. Collectively, this examine aids within the understanding of the molecular drivers, vital genes and pathways that underlie DKD initiation and development.

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