Homozygous missense WIPI2 variants cause a congenital disorder of autophagy with neurodevelopmental impairments of variable clinical severity and disease course

Homozygous missense WIPI2 variants cause a congenital disorder of autophagy with neurodevelopmental impairments of variable clinical severity and disease course

WIPI2 is a member of the human WIPI protein household (seven-bladed b-propeller proteins binding phosphatidylinositols, PROPPINs), which play a pivotal position in autophagy and has been implicated within the pathogenesis of a number of neurological situations.
The homozygous WIPI2 variant c.745G>A; p.(Val249Met) (NM_015610.4) has not too long ago been related to a neurodevelopmental dysfunction in a single household. Utilizing exome sequencing and Sanger segregation evaluation, right here, two novel homozygous WIPI2 variants [c.551T>G; p.(Val184Gly) and c.724C>T; p.(Arg242Trp) (NM_015610.4)] had been recognized in 4 people of two consanguineous households.
Moreover, follow-up medical information had been sought from the beforehand reported household. Three non-ambulant affected siblings of the primary household harbouring the p.(Val184Gly) missense variant introduced with microcephaly, profound world developmental delay/mental incapacity, refractory childish/childhood-onset epilepsy, progressive tetraplegia with joint contractures and dyskinesia.
In distinction, the proband of the second household carrying the p.(Arg242Trp) missense variant, just like the initially reported WIPI2 instances, introduced with a milder phenotype, encompassing reasonable mental incapacity, speech and visible impairment, autistic options, and an ataxic gait.
Mind MR imaging in 5 sufferers confirmed distinguished white matter involvement with a world discount in quantity, posterior corpus callosum hypoplasia, irregular dentate nuclei and hypoplasia of the inferior cerebellar vermis. To research the practical influence of those novel WIPI2 variants, we overexpressed each in WIPI2-knockout HEK293A cells.
Compared to wildtype, expression of the Val166Gly WIPI2b mutant resulted in a poor rescue of LC3 lipidation whereas Arg224Trp mutant elevated LC3 lipidation, in keeping with the beforehand reported Val231Met variant. These findings assist a dysregulation of the early steps of the autophagy pathway. Collectively, our findings present proof that biallelic WIPI2 variants trigger a neurodevelopmental dysfunction of variable severity and illness course. Our report expands the medical spectrum and establishes WIPI2-associated dysfunction as a congenital problems of autophagy.

Scientific Efficacy and Security of Human Mesenchymal Stem Cell Remedy for Degenerative Disc Illness: A Systematic Overview and Meta-Evaluation of Randomized Managed Trials

Degenerative disc illness (DDD) may cause extreme low again ache, which can have a severe detrimental influence on the flexibility to carry out each day duties or actions. For the previous few years, mesenchymal stem cell (MSC) transplantation has emerged as a promising technique for the therapy of DDD.
Nevertheless, the medical efficacy of MSC within the therapy of DDD nonetheless lacks medical proof and is controversial. We performed a meta-analysis with randomized managed trials (RCTs) to judge the medical efficacy and security of MSC transplantation in sufferers with DDD. We searched main databases utilizing phrases from the database’s inception by March 2021.
The Cochrane bias danger evaluation device was used to evaluate high quality. The evaluation confirmed that MSC remedy might lower visible analog scale (VAS) scores (SMD = -0.50, 95%CI = -0.68 ~ -0.33, P < 0.00001) and Oswestry Incapacity Index (ODI) scores (SMD = -0.27, 95%CI = -0.44 ~ -0.09, P = 0.003). The outcomes with subgroup evaluation confirmed that MSC remedy might lower VAS scores in Three months (P = 0.001), 6 months (P = 0.01), 12 months (P = 0.02), and ≥24 months (P = 0.002) and ODI scores in ≥24 months (P = 0.006).
Pooled evaluation confirmed that MSC remedy has the next ratio of sufferers at most thresholds however notably on the MIC (minimally vital change) (P = 0.0002) and CSC (clinically vital change) (P = 0.0002) in VAS and MIC (P = 0.0005) and CSC (P = 0.001) ache responders in ODI. Hostile occasions (AE) of treatment-emergent opposed occasions (TEAE), again ache, arthralgia, and muscle spasms weren’t statistically vital between the 2 teams.
Nevertheless, our additional statistical evaluation confirmed that MSC remedy might induce AE of TEAE associated to review therapy (OR = 3.05, 95%CI = 1.11 ~ 8.40, P = 0.03). In conclusion, this examine pooled the primary outcomes and confirmed that MSC remedy might considerably lower VAS and ODI scores in sufferers with DDD. Distinctly, the findings of this meta-analysis counsel a novel therapeutic technique for sufferers with persistent low again ache (LBP) and lumbar dysfunction by DDD.

Complete-Blood Mitochondrial DNA Copies Are Related With the Prognosis of Acute Respiratory Misery Syndrome After Sepsis

Acute respiratory misery syndrome (ARDS) is an inflammatory means of the lungs that develops primarily in response to pulmonary or systemic sepsis, leading to a disproportionate demise toll in intensive care items (ICUs). Given its position as a vital activator of the inflammatory and innate immune responses, earlier research have reported that a rise of circulating cell-free mitochondrial DNA (mtDNA) is a biomarker for deadly end result within the ICU.
Right here we analyzed the affiliation of whole-blood mtDNA (wb-mtDNA) copies with 28-day survival from sepsis and sepsis-associated ARDS. We analyzed mtDNA information from 687 peripheral whole-blood samples inside 24 h of sepsis prognosis from unrelated Spanish sufferers with sepsis (264 with ARDS) included within the GEN-SEP examine.
The wb-mtDNA copies had been obtained from the array intensities of chosen probes, with 100% id with mtDNA and with the biggest variety of mismatches with the nuclear sequences, and normalized throughout the individual-probe intensities. We used Cox regression fashions for testing the affiliation with 28-day survival.
We noticed that wb-mtDNA copies had been considerably related to 28-day survival in ARDS sufferers (hazard ratio = 3.65, 95% confidence interval = 1.39-9.59, p = 0.009) however not in non-ARDS sufferers. Our findings assist that wb-mtDNA copies at sepsis prognosis might be thought of an early prognostic biomarker in sepsis-associated ARDS sufferers. Future research might be wanted to judge the mechanistic hyperlinks of this commentary with the pathogenesis of ARDS.

Identification of Key Candidate Genes and Chemical Perturbagens in Diabetic Kidney Illness Utilizing Built-in Bioinformatics Evaluation

Globally, almost 40 p.c of all diabetic sufferers develop severe diabetic kidney illness (DKD). The identification of the potential early-stage biomarkers and elucidation of their underlying molecular mechanisms in DKD are required. On this examine, we carried out built-in bioinformatics evaluation on the expression profiles GSE111154, GSE30528 and GSE30529 related to early diabetic nephropathy (EDN), glomerular DKD (GDKD) and tubular DKD (TDKD), respectively.
A complete of 1,241, 318 and 280 differentially expressed genes (DEGs) had been recognized for GSE30258, GSE30529, and GSE111154 respectively. Subsequently, 280 upregulated and 27 downregulated DEGs shared between the three GSE datasets had been recognized.
Additional evaluation of the gene expression ranges performed on the hub genes revealed SPARC (Secreted Protein Acidic And Cysteine Wealthy), POSTN (periostin), LUM (Lumican), KNG1 (Kininogen 1), FN1 (Fibronectin 1), VCAN (Versican) and PTPRO (Protein Tyrosine Phosphatase Receptor Kind O) having potential roles in DKD development.
FN1, LUM and VCAN had been recognized as upregulated genes for GDKD whereas the downregulation of PTPRO was related to all three illnesses. Each POSTN and SPARC had been recognized because the overexpressed putative biomarkers whereas KNG1 was discovered as downregulated in TDKD.

Williams-Beuren Syndrome Chromosomal Region 27 Protein (WBSCR27) Antibody

abx025778-400ul 400 ul
EUR 627.6

Williams-Beuren Syndrome Chromosomal Region 27 Protein (WBSCR27) Antibody

abx025778-80l 80 µl
EUR 343.2

Williams-Beuren Syndrome Chromosomal Region 27 Protein (WBSCR28) Antibody

20-abx307819
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Williams-Beuren Syndrome Chromosomal Region 11 Protein (WBSCR11) Antibody

20-abx215754
  • EUR 510.00
  • EUR 410.40
  • 100 ug
  • 50 ug

Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) Antibody

20-abx171618
  • EUR 1111.20
  • EUR 560.40
  • 1 mg
  • 200 ug

Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) Antibody

20-abx129047
  • EUR 543.60
  • EUR 159.60
  • EUR 1579.20
  • EUR 744.00
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) Antibody (Biotin)

20-abx274484
  • EUR 577.20
  • EUR 292.80
  • EUR 1713.60
  • EUR 811.20
  • EUR 427.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Recombinant Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1)

4-RPL307Hu01
  • EUR 636.10
  • EUR 294.00
  • EUR 2055.36
  • EUR 765.12
  • EUR 1410.24
  • EUR 501.60
  • EUR 4958.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Cat Eye Syndrome Chromosome Region, Candidate 1 expressed in: E.coli

99445-16 DCT 16 X 100MM

99445-16 250/pk
EUR 115.2
Description: Disposable Culture Tubes; DCT's, CGW

Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) Polyclonal Antibody (Human)

4-PAL307Hu01
  • EUR 314.40
  • EUR 3296.40
  • EUR 814.80
  • EUR 397.20
  • EUR 264.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1)

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) Protein

20-abx167165
  • EUR 878.40
  • EUR 343.20
  • EUR 2766.00
  • EUR 1062.00
  • EUR 627.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) Polyclonal Antibody (Human), APC

4-PAL307Hu01-APC
  • EUR 441.60
  • EUR 4318.80
  • EUR 1191.60
  • EUR 566.40
  • EUR 274.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1). This antibody is labeled with APC.

Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) Polyclonal Antibody (Human), Biotinylated

4-PAL307Hu01-Biotin
  • EUR 393.60
  • EUR 3236.40
  • EUR 943.20
  • EUR 484.80
  • EUR 271.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1). This antibody is labeled with Biotin.

Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) Polyclonal Antibody (Human), Cy3

4-PAL307Hu01-Cy3
  • EUR 538.80
  • EUR 5708.40
  • EUR 1539.60
  • EUR 705.60
  • EUR 316.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1). This antibody is labeled with Cy3.

Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) Polyclonal Antibody (Human), FITC

4-PAL307Hu01-FITC
  • EUR 376.80
  • EUR 3478.80
  • EUR 976.80
  • EUR 476.40
  • EUR 243.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1). This antibody is labeled with FITC.

Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) Polyclonal Antibody (Human), HRP

4-PAL307Hu01-HRP
  • EUR 402.00
  • EUR 3762.00
  • EUR 1052.40
  • EUR 511.20
  • EUR 258.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1). This antibody is labeled with HRP.

Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) Polyclonal Antibody (Human), PE

4-PAL307Hu01-PE
  • EUR 376.80
  • EUR 3478.80
  • EUR 976.80
  • EUR 476.40
  • EUR 243.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1). This antibody is labeled with PE.

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit

DLR-CECR1-Hu-48T 48T
EUR 664.8
Description: A sandwich quantitative ELISA assay kit for detection of Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) in samples from serum, plasma or other biological fluids.

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit

DLR-CECR1-Hu-96T 96T
EUR 870
Description: A sandwich quantitative ELISA assay kit for detection of Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) in samples from serum, plasma or other biological fluids.

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit

20-abx151029
  • EUR 8853.60
  • EUR 4719.60
  • EUR 1093.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit

abx055599-96tests 96 tests
EUR 904.8

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit

abx250398-96tests 96 tests
EUR 904.8

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) CLIA Kit

20-abx190184
  • EUR 9493.20
  • EUR 5058.00
  • EUR 1167.60
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

CECR1 Cat Eye Syndrome Chromosome Region Candidate 1 Human Recombinant Protein

PROTQ9NZK5 Regular: 10ug
EUR 380.4
Description: CECR1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 490 amino acids (30-511a.a.) and having a molecular mass of 56.9kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa).;CECR1 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit

RDR-CECR1-Hu-48Tests 48 Tests
EUR 706.8

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit

RDR-CECR1-Hu-96Tests 96 Tests
EUR 984

Human Cat Eye Syndrome Chromosome Region, Candidate 1(CECR1) ELISA Kit

QY-E02201 96T
EUR 433.2

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit

RD-CECR1-Hu-48Tests 48 Tests
EUR 675.6

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit

RD-CECR1-Hu-96Tests 96 Tests
EUR 939.6

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit

SEL307Hu-10x96wellstestplate 10x96-wells test plate
EUR 6227.58
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) in serum, plasma and other biological fluids.

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit

SEL307Hu-1x48wellstestplate 1x48-wells test plate
EUR 618.04
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) in serum, plasma and other biological fluids.

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit

SEL307Hu-1x96wellstestplate 1x96-wells test plate
EUR 831.48
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) in serum, plasma and other biological fluids.

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit

SEL307Hu-5x96wellstestplate 5x96-wells test plate
EUR 3381.66
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) in serum, plasma and other biological fluids.

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) ELISA Kit

4-SEL307Hu
  • EUR 6288.00
  • EUR 3322.80
  • EUR 831.60
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) in samples from Serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1)CLIA Kit

SCL307Hu-10x96wellstestplate 10x96-wells test plate
EUR 6777.36
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) in serum, plasma and other biological fluids.

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1)CLIA Kit

SCL307Hu-1x48wellstestplate 1x48-wells test plate
EUR 663.31
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) in serum, plasma and other biological fluids.

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1)CLIA Kit

SCL307Hu-1x96wellstestplate 1x96-wells test plate
EUR 896.16
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) in serum, plasma and other biological fluids.

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1)CLIA Kit

SCL307Hu-5x96wellstestplate 5x96-wells test plate
EUR 3672.72
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) in serum, plasma and other biological fluids.

Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) CLIA Kit

4-SCL307Hu
  • EUR 6837.60
  • EUR 3673.20
  • EUR 896.40
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1)Serum, plasma and other biological fluids

Human Cat Eye Syndrome Chromosome Region, Candidate 1 ELISA Kit (CECR1)

RK01087 96 Tests
EUR 625.2

Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) Polyclonal Antibody (Human), APC-Cy7

4-PAL307Hu01-APC-Cy7
  • EUR 739.20
  • EUR 8493.60
  • EUR 2240.40
  • EUR 988.80
  • EUR 405.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1). This antibody is labeled with APC-Cy7.

ELISA kit for Human CECR1 (Cat Eye Syndrome Chromosome Region, Candidate 1)

E-EL-H5495 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human CECR1 (Cat Eye Syndrome Chromosome Region, Candidate 1) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human CECR1 (Cat Eye Syndrome Chromosome Region, Candidate 1)

ELK6564 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Cat Eye Syndrome Chromosome Region, Candidate 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

RA420A-miR-16 QuantiMir miR-16 --50 assays

RA420A-miR-16 50 assays
EUR 181.2

0.5-10UL ADJUSTABLE VOLUME 16 CHANNEL AXYPET PIPETTOR

AP-16 1/pk
EUR 750
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

Williams' Medium E

CM063-050 500ml
EUR 109.2

Williams' Medium E

CM063-300 6x500ml
EUR 319.2

Williams' Medium E

CM063-310 10x500ml
EUR 375.6

Williams' Medium E

CM063-320 20x500ml
EUR 724.8

Williams' Medium E

CM063-350 50x500ml
EUR 1170

CPX Chromosome Region, Candidate 1 (CPXCR1) Antibody

abx145283-100ug 100 ug
EUR 469.2

CPX Chromosome Region, Candidate 1 (CPXCR1) Antibody

20-abx148870
  • EUR 510.00
  • EUR 410.40
  • 100 ug
  • 50 ug

CPX Chromosome Region, Candidate 1 (CPXCR1) Antibody

abx231948-100ug 100 ug
EUR 610.8

CPX Chromosome Region, Candidate 1 (CPXCR1) Antibody

20-abx318624
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

99449 DSSCT 16 X 100MM W/O MARKING SPOT

99449-16 250/pk
EUR 354
Description: Disposable Screw Cap Culture Tubes; DSCCT's, Lab Stock

DiGeorge Syndrome Critical Region 14 (DGCR14) Antibody

abx027696-400ul 400 ul
EUR 627.6

DiGeorge Syndrome Critical Region 14 (DGCR14) Antibody

abx027696-80l 80 µl
EUR 343.2

DiGeorge Syndrome Critical Region 6 (DGCR6) Antibody

abx034439-400ul 400 ul
EUR 627.6

DiGeorge Syndrome Critical Region 6 (DGCR6) Antibody

abx034439-80l 80 µl
EUR 343.2

99448 DSSCT 16 X 125MM FLAT BOTTOM W/O MARKING SPOT

99448-16 250/pk
EUR 430.8
Description: Disposable Screw Cap Culture Tubes; DSCCT's, Lab Stock

Chromosome 16 Open Reading Frame 14 (MCRIP2) Antibody

20-abx111660
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Chromosome 16 Open Reading Frame 70 (C16ORF70) Antibody

20-abx111661
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Chromosome 16 Open Reading Frame 45 (C16orf45) Antibody

abx231034-100ug 100 ug
EUR 610.8

Chromosome 16 Open Reading Frame 70 (C16orf70) Antibody

abx231036-100ug 100 ug
EUR 577.2

Chromosome 16 Open Reading Frame 72 (C16orf72) Antibody

abx231037-100ug 100 ug
EUR 610.8

Chromosome 16 Open Reading Frame 78 (C16ORF78) Antibody

20-abx301590
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Chromosome 16 Open Reading Frame 62 (C16ORF62) Antibody

20-abx302517
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Chromosome 16 Open Reading Frame 87 (C16ORF87) Antibody

20-abx308129
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Nucleo 9 Line 16 ELISA kit

55R-ORG711/16 16 Tests
EUR 478.8
Description: ELISA kit for the detection of Nucleo 9 Line 16 in the research laboratory

Chromosome Region Maintenance 1 Protein Homolog (CRM1) Antibody

abx231984-100ug 100 ug
EUR 577.2

CPX Chromosome Region, Candidate 1 (CPXCR1) Antibody (HRP)

20-abx308950
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

CPX Chromosome Region, Candidate 1 (CPXCR1) Antibody (FITC)

20-abx308951
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

CPX Chromosome Region, Candidate 1 (CPXCR1) Antibody (Biotin)

20-abx308952
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Chromosome 16 Open Reading Frame 53 Protein

20-abx261376
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

ANA 9 Line Immunoblot 16 ELISA kit

55R-ORG710/16 16 Tests
EUR 478.8
Description: ELISA kit for the detection of ANA 9 Line Immunoblot 16 in the research laboratory

DiGeorge Syndrome Critical Region Gene 8 (DGCR8) Antibody

abx149799-100ug 100 ug
EUR 526.8

DiGeorge Syndrome Critical Region Gene 2 (DGCR2) Antibody

abx122722-100ug 100 ug
EUR 469.2

DiGeorge Syndrome Critical Region Gene 8 (DGCR8) Antibody

20-abx125324
  • EUR 594.00
  • EUR 844.80
  • EUR 427.20
  • 100 ul
  • 200 ul
  • 50 ul

DiGeorge Syndrome Critical Region Gene 2 (DGCR2) Antibody

20-abx112067
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

DiGeorge Syndrome Critical Region Gene 8 (DGCR8) Antibody

20-abx112069
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

DiGeorge Syndrome Critical Region Gene 8 (DGCR8) Antibody

20-abx004627
  • EUR 594.00
  • EUR 427.20
  • 100 ul
  • 50 ul

Down Syndrome Critical Region Protein 1 (DSCR1) Antibody

20-abx009324
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

DiGeorge Syndrome Critical Region Gene 8 (DGCR8) Antibody

abx037930-100ug 100 ug
EUR 469.2

Down Syndrome Critical Region Protein 3 (DSCR3) Antibody

abx032797-400ul 400 ul
EUR 627.6

Down Syndrome Critical Region Protein 3 (DSCR3) Antibody

abx032797-80l 80 µl
EUR 343.2

DiGeorge Syndrome Critical Region Gene 8 (DGCR8) Antibody

abx034165-400ul 400 ul
EUR 627.6

DiGeorge Syndrome Critical Region Gene 8 (DGCR8) Antibody

abx034165-80l 80 µl
EUR 343.2

DiGeorge Syndrome Critical Region Gene 2 (DGCR2) Antibody

abx034378-400ul 400 ul
EUR 627.6

DiGeorge Syndrome Critical Region Gene 2 (DGCR2) Antibody

abx034378-80l 80 µl
EUR 343.2

DiGeorge Syndrome Critical Region Gene 8 (DGCR8) Antibody

abx037565-100ug 100 ug
EUR 469.2

Down Syndrome Critical Region Protein 1 (DSCR1) Antibody

abx025110-400ul 400 ul
EUR 627.6

Down Syndrome Critical Region Protein 1 (DSCR1) Antibody

abx025110-80l 80 µl
EUR 343.2

Down Syndrome Critical Region Protein 1 (DSCR1) Antibody

abx025111-400ul 400 ul
EUR 627.6

Down Syndrome Critical Region Protein 1 (DSCR1) Antibody

abx025111-80l 80 µl
EUR 343.2

DiGeorge Syndrome Critical Region Gene 2 (DGCR2) Antibody

abx232350-100ug 100 ug
EUR 610.8

DiGeorge Syndrome Critical Region Gene 8 (DGCR8) Antibody

abx232351-100ug 100 ug
EUR 577.2

DiGeorge Syndrome Critical Region Gene 8 (DGCR8) Antibody

abx232352-100ug 100 ug
EUR 661.2

DiGeorge Syndrome Critical Region Gene 8 (DGCR8) Antibody

abx232353-100ug 100 ug
EUR 610.8

Down Syndrome Critical Region Protein 2 (DSCR2) Antibody

abx430430-200ul 200 ul
EUR 460.8

DiGeorge Syndrome Critical Region Gene 8 (DGCR8) Antibody

abx430470-200ul 200 ul
EUR 343.2

Down Syndrome Critical Region Protein 9 (DSCR9) Antibody

20-abx301178
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Putative BPES Syndrome Breakpoint Region Protein (BPESC1) Antibody

20-abx311773
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Down Syndrome Critical Region Protein 4 (DSCR4) Antibody

20-abx303669
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Chromosome 16 Open Reading Frame 62 (C16ORF62) Antibody (HRP)

20-abx316352
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Chromosome 16 Open Reading Frame 62 (C16ORF62) Antibody (FITC)

20-abx316353
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Chromosome 16 Open Reading Frame 62 (C16ORF62) Antibody (Biotin)

20-abx316354
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Chromosome 16 Open Reading Frame 78 (C16ORF78) Antibody (HRP)

20-abx309975
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Chromosome 16 Open Reading Frame 78 (C16ORF78) Antibody (FITC)

20-abx309976
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Chromosome 16 Open Reading Frame 78 (C16ORF78) Antibody (Biotin)

20-abx309977
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Chromosome 16 Open Reading Frame 87 (C16ORF87) Antibody (HRP)

20-abx308130
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Chromosome 16 Open Reading Frame 87 (C16ORF87) Antibody (FITC)

20-abx308131
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Chromosome 16 Open Reading Frame 87 (C16ORF87) Antibody (Biotin)

20-abx308132
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

0.2-2UL ADJUSTABLE VOLUME 16 CHANNEL AXYPET PIPETTOR

AP-16-2 1/pk
EUR 750
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

5-50UL ADJUSTABLE VOLUME 16 CHANNEL AXYPET PIPETTOR

AP-16-50 1/pk
EUR 750
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

Amyotrophic Lateral Sclerosis 2 Chromosome Region 12 (ALS2CR12) Antibody

20-abx338368
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

DiGeorge Syndrome Critical Region Gene 6 Protein

20-abx261930
  • EUR 5388.00
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Recombinant Human Chromosome 16 Open Reading Frame 53

7-04633 5µg Ask for price

Recombinant Human Chromosome 16 Open Reading Frame 53

7-04634 20µg Ask for price

Recombinant Human Chromosome 16 Open Reading Frame 53

7-04635 1mg Ask for price

Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1

PR27224 2 ug
EUR 229.2

Cat Eye Syndrome Critical Region Protein 2 (CECR2) Antibody

20-abx136053
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Digeorge Syndrome Critical Region Gene 6-Like (DGCR6L) Antibody

20-abx112068
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Cat Eye Syndrome Critical Region Protein 5 (CECR5) Antibody

abx033997-400ul 400 ul
EUR 627.6

Cat Eye Syndrome Critical Region Protein 5 (CECR5) Antibody

abx033997-80l 80 µl
EUR 343.2

Cat Eye Syndrome Critical Region Protein 6 (CECR6) Antibody

abx029845-400ul 400 ul
EUR 627.6

Cat Eye Syndrome Critical Region Protein 6 (CECR6) Antibody

abx029845-80l 80 µl
EUR 343.2

Cat Eye Syndrome Critical Region Protein 2 (CECR2) Antibody

abx432490-200ul 200 ul
EUR 343.2

DiGeorge Syndrome Critical Region 6-Like Protein (DGCR6L) Antibody

20-abx318669
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Amyotrophic Lateral Sclerosis 2 Chromosome Region 12 (ALS2CR12) Antibody (HRP)

20-abx334692
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Amyotrophic Lateral Sclerosis 2 Chromosome Region 12 (ALS2CR12) Antibody (FITC)

20-abx334693
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Amyotrophic Lateral Sclerosis 2 Chromosome Region 12 (ALS2CR12) Antibody (Biotin)

20-abx334694
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

T4 (Thyroxine) ELISA test

16 96T/Box Ask for price
Description: ELISA based test for quantitative detection of T4 (Thyroxine)

DiGeorge Syndrome Critical Region Gene 6-Like Protein

20-abx263350
  • EUR 1930.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

Recombinant (E.Coli) Human Down Syndrome Critical Region 1

RP-785 5 ug
EUR 196.8

Anti-Phospho-DiGeorge Syndrome Critical Region 8 DGCR8 (Ser377) Antibody

P00475 100ul
EUR 477.6
Description: Rabbit Polyclonal Phospho-DiGeorge Syndrome Critical Region 8 DGCR8 (Ser377) Antibody. Validated in WB and tested in Human, Mouse.

MKS1 Antibody / Meckel syndrome type 1 protein (N-Terminal Region)

F54181-0.05ML 0.05 ml
EUR 165

MKS1 Antibody / Meckel syndrome type 1 protein (N-Terminal Region)

F54181-0.2ML 0.2 ml
EUR 379

MKS1 Antibody / Meckel syndrome type 1 protein (N-Terminal Region)

F54182-0.05ML 0.05 ml
EUR 165

MKS1 Antibody / Meckel syndrome type 1 protein (N-Terminal Region)

F54182-0.2ML 0.2 ml
EUR 379

Human CPX Chromosome Region, Candidate 1 (CPXCR1) ELISA Kit

abx384735-96tests 96 tests
EUR 1093.2

Mouse CPX Chromosome Region, Candidate 1 (CPXCR1) ELISA Kit

abx388923-96tests 96 tests
EUR 1093.2

Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 Protein

20-abx263361
  • EUR 1930.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

AXYGEN® 16-WELL COMB FOR USE WITH 10 CM GEL BOX, 0.75 MM THICKNESS

HGB10-16-075 1/pk
EUR 67.2
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® 16-WELL COMB FOR USE WITH 10 CM GEL BOX, 1.0 MM THICKNESS

HGB10-16-1 1/pk
EUR 68.4
Description: Lab Equipment; Axygen Branded EQ
Moreover, we additionally recognized two medication, particularly pidorubicine, a topoisomerase inhibitor (LINCS ID- BRD-Okay04548931) and Polo-like kinase inhibitor (LINCS ID- BRD-Okay41652870) having the validated position in reversing the differential gene expression patterns noticed within the three GSE datasets used. Collectively, this examine aids within the understanding of the molecular drivers, vital genes and pathways that underlie DKD initiation and development.

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