Assay Blocking calprotectin elisa Elisa hama antibodies hmgb1 elisa iron assay Isotype Monoclonal p24 elisa Pcr pge2 elisa plc gamma 2 protein carbonyl assay protein carbonyls Recombinant rna Serum tbars assay kit tdgf1 triglyceride assay Vector
Homozygous missense WIPI2 variants cause a congenital disorder of autophagy with neurodevelopmental impairments of variable clinical severity and disease course
WIPI2 is a member of the human WIPI protein household (seven-bladed b-propeller proteins binding phosphatidylinositols, PROPPINs), which play a pivotal position in autophagy and has been implicated within the pathogenesis of a number of neurological situations.
The homozygous WIPI2 variant c.745G>A; p.(Val249Met) (NM_015610.4) has not too long ago been related to a neurodevelopmental dysfunction in a single household. Utilizing exome sequencing and Sanger segregation evaluation, right here, two novel homozygous WIPI2 variants [c.551T>G; p.(Val184Gly) and c.724C>T; p.(Arg242Trp) (NM_015610.4)] had been recognized in 4 people of two consanguineous households.
Moreover, follow-up medical information had been sought from the beforehand reported household. Three non-ambulant affected siblings of the primary household harbouring the p.(Val184Gly) missense variant introduced with microcephaly, profound world developmental delay/mental incapacity, refractory childish/childhood-onset epilepsy, progressive tetraplegia with joint contractures and dyskinesia.
In distinction, the proband of the second household carrying the p.(Arg242Trp) missense variant, just like the initially reported WIPI2 instances, introduced with a milder phenotype, encompassing reasonable mental incapacity, speech and visible impairment, autistic options, and an ataxic gait.
Mind MR imaging in 5 sufferers confirmed distinguished white matter involvement with a world discount in quantity, posterior corpus callosum hypoplasia, irregular dentate nuclei and hypoplasia of the inferior cerebellar vermis. To research the practical influence of those novel WIPI2 variants, we overexpressed each in WIPI2-knockout HEK293A cells.
Compared to wildtype, expression of the Val166Gly WIPI2b mutant resulted in a poor rescue of LC3 lipidation whereas Arg224Trp mutant elevated LC3 lipidation, in keeping with the beforehand reported Val231Met variant. These findings assist a dysregulation of the early steps of the autophagy pathway. Collectively, our findings present proof that biallelic WIPI2 variants trigger a neurodevelopmental dysfunction of variable severity and illness course. Our report expands the medical spectrum and establishes WIPI2-associated dysfunction as a congenital problems of autophagy.
Scientific Efficacy and Security of Human Mesenchymal Stem Cell Remedy for Degenerative Disc Illness: A Systematic Overview and Meta-Evaluation of Randomized Managed Trials
Degenerative disc illness (DDD) may cause extreme low again ache, which can have a severe detrimental influence on the flexibility to carry out each day duties or actions. For the previous few years, mesenchymal stem cell (MSC) transplantation has emerged as a promising technique for the therapy of DDD.
Nevertheless, the medical efficacy of MSC within the therapy of DDD nonetheless lacks medical proof and is controversial. We performed a meta-analysis with randomized managed trials (RCTs) to judge the medical efficacy and security of MSC transplantation in sufferers with DDD. We searched main databases utilizing phrases from the database’s inception by March 2021.
The Cochrane bias danger evaluation device was used to evaluate high quality. The evaluation confirmed that MSC remedy might lower visible analog scale (VAS) scores (SMD = -0.50, 95%CI = -0.68 ~ -0.33, P < 0.00001) and Oswestry Incapacity Index (ODI) scores (SMD = -0.27, 95%CI = -0.44 ~ -0.09, P = 0.003). The outcomes with subgroup evaluation confirmed that MSC remedy might lower VAS scores in Three months (P = 0.001), 6 months (P = 0.01), 12 months (P = 0.02), and ≥24 months (P = 0.002) and ODI scores in ≥24 months (P = 0.006).
Pooled evaluation confirmed that MSC remedy has the next ratio of sufferers at most thresholds however notably on the MIC (minimally vital change) (P = 0.0002) and CSC (clinically vital change) (P = 0.0002) in VAS and MIC (P = 0.0005) and CSC (P = 0.001) ache responders in ODI. Hostile occasions (AE) of treatment-emergent opposed occasions (TEAE), again ache, arthralgia, and muscle spasms weren’t statistically vital between the 2 teams.
Nevertheless, our additional statistical evaluation confirmed that MSC remedy might induce AE of TEAE associated to review therapy (OR = 3.05, 95%CI = 1.11 ~ 8.40, P = 0.03). In conclusion, this examine pooled the primary outcomes and confirmed that MSC remedy might considerably lower VAS and ODI scores in sufferers with DDD. Distinctly, the findings of this meta-analysis counsel a novel therapeutic technique for sufferers with persistent low again ache (LBP) and lumbar dysfunction by DDD.
Complete-Blood Mitochondrial DNA Copies Are Related With the Prognosis of Acute Respiratory Misery Syndrome After Sepsis
Acute respiratory misery syndrome (ARDS) is an inflammatory means of the lungs that develops primarily in response to pulmonary or systemic sepsis, leading to a disproportionate demise toll in intensive care items (ICUs). Given its position as a vital activator of the inflammatory and innate immune responses, earlier research have reported that a rise of circulating cell-free mitochondrial DNA (mtDNA) is a biomarker for deadly end result within the ICU.
Right here we analyzed the affiliation of whole-blood mtDNA (wb-mtDNA) copies with 28-day survival from sepsis and sepsis-associated ARDS. We analyzed mtDNA information from 687 peripheral whole-blood samples inside 24 h of sepsis prognosis from unrelated Spanish sufferers with sepsis (264 with ARDS) included within the GEN-SEP examine.
The wb-mtDNA copies had been obtained from the array intensities of chosen probes, with 100% id with mtDNA and with the biggest variety of mismatches with the nuclear sequences, and normalized throughout the individual-probe intensities. We used Cox regression fashions for testing the affiliation with 28-day survival.
We noticed that wb-mtDNA copies had been considerably related to 28-day survival in ARDS sufferers (hazard ratio = 3.65, 95% confidence interval = 1.39-9.59, p = 0.009) however not in non-ARDS sufferers. Our findings assist that wb-mtDNA copies at sepsis prognosis might be thought of an early prognostic biomarker in sepsis-associated ARDS sufferers. Future research might be wanted to judge the mechanistic hyperlinks of this commentary with the pathogenesis of ARDS.
Identification of Key Candidate Genes and Chemical Perturbagens in Diabetic Kidney Illness Utilizing Built-in Bioinformatics Evaluation
Globally, almost 40 p.c of all diabetic sufferers develop severe diabetic kidney illness (DKD). The identification of the potential early-stage biomarkers and elucidation of their underlying molecular mechanisms in DKD are required. On this examine, we carried out built-in bioinformatics evaluation on the expression profiles GSE111154, GSE30528 and GSE30529 related to early diabetic nephropathy (EDN), glomerular DKD (GDKD) and tubular DKD (TDKD), respectively.
A complete of 1,241, 318 and 280 differentially expressed genes (DEGs) had been recognized for GSE30258, GSE30529, and GSE111154 respectively. Subsequently, 280 upregulated and 27 downregulated DEGs shared between the three GSE datasets had been recognized.
Additional evaluation of the gene expression ranges performed on the hub genes revealed SPARC (Secreted Protein Acidic And Cysteine Wealthy), POSTN (periostin), LUM (Lumican), KNG1 (Kininogen 1), FN1 (Fibronectin 1), VCAN (Versican) and PTPRO (Protein Tyrosine Phosphatase Receptor Kind O) having potential roles in DKD development.
FN1, LUM and VCAN had been recognized as upregulated genes for GDKD whereas the downregulation of PTPRO was related to all three illnesses. Each POSTN and SPARC had been recognized because the overexpressed putative biomarkers whereas KNG1 was discovered as downregulated in TDKD.
Wbscr27 (GFP-tagged) - Mouse Williams Beuren syndrome chromosome region 27 (human) (Wbscr27) |
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| MG202917 | Origene Technologies GmbH | 10 µg | Ask for price |
WBSCR27 (Myc-DDK-tagged)-Human Williams Beuren syndrome chromosome region 27 (WBSCR27) |
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| RC207050 | Origene Technologies GmbH | 10 µg | Ask for price |
Wbscr27 (untagged) - Mouse Williams Beuren syndrome chromosome region 27 (human) (Wbscr27), (10ug) |
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| MC200240 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Human Williams Beuren syndrome chromosome region 27 (WBSCR27), mGFP tagged |
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| RC207050L4 | Origene Technologies GmbH | 10 µg | Ask for price |
Wbscr27 (Myc-DDK-tagged) - Mouse Williams Beuren syndrome chromosome region 27 (human) (Wbscr27) |
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| MR202917 | Origene Technologies GmbH | 10 µg | Ask for price |
Williams-Beuren Syndrome Chromosome Region 16 Antibody |
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| 20-abx116668 | Abbexa |
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Williams-Beuren Syndrome Chromosome Region 16 Antibody |
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| abx116668-100g | Abbexa | 100 µg | EUR 612.5 |
Wbscr27 (Myc-DDK-tagged ORF) - Rat Williams Beuren syndrome chromosome region 27 (Wbscr27), (10 ug) |
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| RR208770 | Origene Technologies GmbH | 10 µg | Ask for price |
Wbscr22 (Myc-DDK-tagged ORF) - Rat Williams Beuren syndrome chromosome region 22 (Wbscr22), (10 ug) |
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| RR204282 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Human Williams Beuren syndrome chromosome region 27 (WBSCR27), Myc-DDK-tagged |
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| RC207050L3 | Origene Technologies GmbH | 10 µg | Ask for price |
3`UTR clone of Williams Beuren syndrome chromosome region 22 (WBSCR22) for miRNA target validation |
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| SC204759 | Origene Technologies GmbH | 10 µg | Ask for price |
WBSCR22 (untagged)-Human Williams Beuren syndrome chromosome region 22 (WBSCR22), transcript variant 2 |
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| SC320894 | Origene Technologies GmbH | 10 µg | Ask for price |
WBSCR22 (untagged)-Human Williams Beuren syndrome chromosome region 22 (WBSCR22), transcript variant 2 |
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| SC127812 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Wbscr22 (mGFP-tagged) - Mouse Williams Beuren syndrome chromosome region 22 (Wbscr22) |
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| MR212791L4 | Origene Technologies GmbH | 10 µg | Ask for price |
WBSCR22 (GFP-tagged) - Human Williams Beuren syndrome chromosome region 22 (WBSCR22), transcript variant 2 |
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| RG204043 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Wbscr22 (Myc-DDK-tagged) - Mouse Williams Beuren syndrome chromosome region 22 (Wbscr22) |
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| MR212791L3 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Wbscr27 (mGFP-tagged) - Mouse Williams Beuren syndrome chromosome region 27 (human) (Wbscr27) |
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| MR202917L4 | Origene Technologies GmbH | 10 µg | Ask for price |
WBSCR22 (untagged) - Homo sapiens Williams Beuren syndrome chromosome region 22 (WBSCR22), transcript variant 1 |
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| SC329680 | Origene Technologies GmbH | 10 µg | Ask for price |
WBSCR27 (untagged)-Human Williams Beuren syndrome chromosome region 27 (cDNA clone MGC:40131 IMAGE:5396423), complete cds |
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| SC123504 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Wbscr27 (mGFP-tagged ORF) - Rat Williams Beuren syndrome chromosome region 27 (Wbscr27), (10 ug) |
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| RR208770L4 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Wbscr22 (mGFP-tagged ORF) - Rat Williams Beuren syndrome chromosome region 22 (Wbscr22), (10 ug) |
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| RR204282L4 | Origene Technologies GmbH | 10 µg | Ask for price |
WBSCR22 (Myc-DDK-tagged)-Human Williams Beuren syndrome chromosome region 22 (WBSCR22), transcript variant 2 |
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| RC204043 | Origene Technologies GmbH | 10 µg | Ask for price |
WBSCR22 (GFP-tagged) - Homo sapiens Williams Beuren syndrome chromosome region 22 (WBSCR22), transcript variant 1 |
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| RG232405 | Origene Technologies GmbH | 10 µg | Ask for price |
MLXIPL (untagged)-Human Williams Beuren syndrome chromosome region 14, mRNA (cDNA clone MGC:9556 IMAGE:3866131), complete cds |
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| SC126048 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Wbscr27 (Myc-DDK-tagged) - Mouse Williams Beuren syndrome chromosome region 27 (human) (Wbscr27) |
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| MR202917L3 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Human Williams Beuren syndrome chromosome region 22 (WBSCR22), transcript variant 2, mGFP tagged |
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| RC204043L4 | Origene Technologies GmbH | 10 µg | Ask for price |
WBSCR22 (Myc-DDK tagged) - Homo sapiens Williams Beuren syndrome chromosome region 22 (WBSCR22), transcript variant 1 |
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| RC232405 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Wbscr27 (Myc-DDK-tagged ORF) - Rat Williams Beuren syndrome chromosome region 27 (Wbscr27), (10 ug) |
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| RR208770L3 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Wbscr22 (Myc-DDK-tagged ORF) - Rat Williams Beuren syndrome chromosome region 22 (Wbscr22), (10 ug) |
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| RR204282L3 | Origene Technologies GmbH | 10 µg | Ask for price |
Williams-Beuren Syndrome Chromosome Region 17 Antibody |
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| 20-abx116669 | Abbexa |
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Williams-Beuren Syndrome Chromosome Region 17 Antibody |
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| abx116669-100g | Abbexa | 100 µg | EUR 612.5 |
Lenti ORF particles, Wbscr22 (GFP-tagged) - Mouse Williams Beuren syndrome chromosome region 22 (Wbscr22), 200ul, >10^7 TU/mL |
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| MR212791L4V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, WBSCR27 (mGFP-tagged) - Human Williams Beuren syndrome chromosome region 27 (WBSCR27), 200ul, >10^7 TU/mL |
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| RC207050L4V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF clone of Human Williams Beuren syndrome chromosome region 22 (WBSCR22), transcript variant 2, Myc-DDK-tagged |
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| RC204043L3 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF particles, WBSCR27 (Myc-DDK tagged) - Human Williams Beuren syndrome chromosome region 27 (WBSCR27), 200ul, >10^7 TU/mL |
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| RC207050L3V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, Wbscr27 (GFP-tagged ORF) - Rat Williams Beuren syndrome chromosome region 27 (Wbscr27), 200ul, >10^7 TU/mL |
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| RR208770L4V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, Wbscr22 (GFP-tagged ORF) - Rat Williams Beuren syndrome chromosome region 22 (Wbscr22), 200ul, >10^7 TU/mL |
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| RR204282L4V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, Wbscr27 (Myc-DDK-tagged ORF) - Rat Williams Beuren syndrome chromosome region 27 (Wbscr27), 200ul, >10^7 TU/mL |
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| RR208770L3V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, Wbscr22 (Myc-DDK-tagged ORF) - Rat Williams Beuren syndrome chromosome region 22 (Wbscr22), 200ul, >10^7 TU/mL |
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| RR204282L3V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, Wbscr22 (Myc-DDK-tagged) - Mouse Williams Beuren syndrome chromosome region 22 (Wbscr22), 200ul, >10^7 TU/mL |
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| MR212791L3V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, Wbscr27 (GFP-tagged) - Mouse Williams Beuren syndrome chromosome region 27 (human) (Wbscr27), 200ul, >10^7 TU/mL |
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| MR202917L4V | Origene Technologies GmbH | 200 µl | Ask for price |
WBSCR14 (Williams Beuren Syndrome Chromosome Region 14, Williams-Beuren Syndrome Chromosome Region 14 Protein, Carbohydrate Responsive Element Binding Protein, CHREBP, MIO, MLX Interacting Protein-like, MLXIPL, Mlx Interactor, MONDOB, WS Basic Helix-loop- |
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| MBS619889-01mL | MyBiosource | 0.1mL | EUR 805 |
WBSCR14 (Williams Beuren Syndrome Chromosome Region 14, Williams-Beuren Syndrome Chromosome Region 14 Protein, Carbohydrate Responsive Element Binding Protein, CHREBP, MIO, MLX Interacting Protein-like, MLXIPL, Mlx Interactor, MONDOB, WS Basic Helix-loop- |
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| MBS619889-5x01mL | MyBiosource | 5x0.1mL | EUR 3475 |
WBSCR14 (Williams Beuren Syndrome Chromosome Region 14, Williams-Beuren Syndrome Chromosome Region 14 Protein, Carbohydrate Responsive Element Binding Protein, CHREBP, MIO, MLX Interacting Protein-like, MLXIPL, Mlx Interactor, MONDOB, WS Basic Helix-loop- |
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| MBS621105-01mL | MyBiosource | 0.1mL | EUR 700 |
WBSCR14 (Williams Beuren Syndrome Chromosome Region 14, Williams-Beuren Syndrome Chromosome Region 14 Protein, Carbohydrate Responsive Element Binding Protein, CHREBP, MIO, MLX Interacting Protein-like, MLXIPL, Mlx Interactor, MONDOB, WS Basic Helix-loop- |
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| MBS621105-5x01mL | MyBiosource | 5x0.1mL | EUR 2990 |
WBSCR14 (Williams Beuren Syndrome Chromosome Region 14, Williams-Beuren Syndrome Chromosome Region 14 Protein, Carbohydrate Responsive Element Binding Protein, CHREBP, MIO, MLX Interacting Protein-like, MLXIPL, Mlx Interactor, MONDOB, WS Basic Helix-loop- |
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| MBS620715-01mL | MyBiosource | 0.1mL | EUR 805 |
WBSCR14 (Williams Beuren Syndrome Chromosome Region 14, Williams-Beuren Syndrome Chromosome Region 14 Protein, Carbohydrate Responsive Element Binding Protein, CHREBP, MIO, MLX Interacting Protein-like, MLXIPL, Mlx Interactor, MONDOB, WS Basic Helix-loop- |
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| MBS620715-5x01mL | MyBiosource | 5x0.1mL | EUR 3475 |
WBSCR14 (Williams Beuren Syndrome Chromosome Region 14, Williams-Beuren Syndrome Chromosome Region 14 Protein, Carbohydrate Responsive Element Binding Protein, CHREBP, MIO, MLX Interacting Protein-like, MLXIPL, Mlx Interactor, MONDOB, WS Basic Helix-loop- |
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| MBS623138-0025mL | MyBiosource | 0.025mL | EUR 435 |
WBSCR14 (Williams Beuren Syndrome Chromosome Region 14, Williams-Beuren Syndrome Chromosome Region 14 Protein, Carbohydrate Responsive Element Binding Protein, CHREBP, MIO, MLX Interacting Protein-like, MLXIPL, Mlx Interactor, MONDOB, WS Basic Helix-loop- |
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| MBS623138-01mL | MyBiosource | 0.1mL | EUR 715 |
WBSCR14 (Williams Beuren Syndrome Chromosome Region 14, Williams-Beuren Syndrome Chromosome Region 14 Protein, Carbohydrate Responsive Element Binding Protein, CHREBP, MIO, MLX Interacting Protein-like, MLXIPL, Mlx Interactor, MONDOB, WS Basic Helix-loop- |
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| MBS623138-5x01mL | MyBiosource | 5x0.1mL | EUR 3075 |
Lenti ORF particles, Wbscr27 (Myc-DDK-tagged) - Mouse Williams Beuren syndrome chromosome region 27 (human) (Wbscr27), 200ul, >10^7 TU/mL |
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| MR202917L3V | Origene Technologies GmbH | 200 µl | Ask for price |
Williams-Beuren Syndrome Chromosome Region 4 (CLIP2) Antibody |
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| abx231764-100ug | Abbexa | 100 ug | EUR 610.8 |
Williams-Beuren Syndrome Chromosome Region 4 (CLIP2) Antibody |
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| abx231764-100g | Abbexa | 100 µg | EUR 350 |
Lenti ORF particles, WBSCR22 (Myc-DDK tagged) - Human Williams Beuren syndrome chromosome region 22 (WBSCR22), transcript variant 2, 200ul, >10^7 |
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| RC204043L3V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, WBSCR22 (mGFP-tagged) - Human Williams Beuren syndrome chromosome region 22 (WBSCR22), transcript variant 2, 200ul, >10^7 TU |
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| RC204043L4V | Origene Technologies GmbH | 200 µl | Ask for price |
Rabbit anti-human Williams-Beuren syndrome chromosome region 16 polyclonal Antibody |
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| MBS711280-01mL | MyBiosource | 0.1mL | EUR 485 |
Rabbit anti-human Williams-Beuren syndrome chromosome region 16 polyclonal Antibody |
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| MBS711280-5x01mL | MyBiosource | 5x0.1mL | EUR 2175 |
WBSCR16 (untagged)-Human Williams-Beuren syndrome chromosome region 16 (WBSCR16) |
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| SC110663 | Origene Technologies GmbH | 10 µg | Ask for price |
WBSCR16 (GFP-tagged) - Human Williams-Beuren syndrome chromosome region 16 (WBSCR16) |
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| RG203234 | Origene Technologies GmbH | 10 µg | Ask for price |
Rabbit anti-human Williams-Beuren syndrome chromosome region 17 polyclonal Antibody |
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| MBS710756-01mL | MyBiosource | 0.1mL | EUR 485 |
Rabbit anti-human Williams-Beuren syndrome chromosome region 17 polyclonal Antibody |
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| MBS710756-5x01mL | MyBiosource | 5x0.1mL | EUR 2175 |
WBSCR16 (Myc-DDK-tagged)-Human Williams-Beuren syndrome chromosome region 16 (WBSCR16) |
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| RC203234 | Origene Technologies GmbH | 10 µg | Ask for price |
WBSCR28 (untagged)-Human Williams-Beuren syndrome chromosome region 28 (WBSCR28) |
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| SC123373 | Origene Technologies GmbH | 10 µg | Ask for price |
WBSCR17 (untagged)-Human Williams-Beuren syndrome chromosome region 17 (WBSCR17) |
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| SC111399 | Origene Technologies GmbH | 10 µg | Ask for price |
WSTF (Williams Syndrome Transcription Factor, BAZB1, Bromodomain Adjacent to Zinc Finger Domain 1B, WBSCR9, Williams-Beuren Syndrome Chromosome Region 9, WBSC10, Williams-Beuren Syndrome Chromosone) |
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| MBS610881-01mL | MyBiosource | 0.1mL | EUR 660 |
WSTF (Williams Syndrome Transcription Factor, BAZB1, Bromodomain Adjacent to Zinc Finger Domain 1B, WBSCR9, Williams-Beuren Syndrome Chromosome Region 9, WBSC10, Williams-Beuren Syndrome Chromosone) |
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| MBS610881-5x01mL | MyBiosource | 5x0.1mL | EUR 2810 |
Wbscr16 (untagged) - Mouse Williams-Beuren syndrome chromosome region 16 homolog (human) (Wbscr16), (10ug) |
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| MC201720 | Origene Technologies GmbH | 10 µg | Ask for price |
Wbscr16 (GFP-tagged) - Mouse Williams-Beuren syndrome chromosome region 16 homolog (human) (Wbscr16) |
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| MG207363 | Origene Technologies GmbH | 10 µg | Ask for price |
WBSCR17 (GFP-tagged) - Human Williams-Beuren syndrome chromosome region 17 (WBSCR17) |
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| RG212796 | Origene Technologies GmbH | 10 µg | Ask for price |
WBSCR28 (GFP-tagged) - Human Williams-Beuren syndrome chromosome region 28 (WBSCR28) |
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| RG205458 | Origene Technologies GmbH | 10 µg | Ask for price |
WBSCR16 (untagged) - Human Williams-Beuren syndrome chromosome region 16 (WBSCR16), transcript variant 2 |
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| SC336210 | Origene Technologies GmbH | 10 µg | Ask for price |
WBSCR16 (untagged) - Human Williams-Beuren syndrome chromosome region 16 (WBSCR16), transcript variant 3 |
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| SC335598 | Origene Technologies GmbH | 10 µg | Ask for price |
Williams-Beuren Syndrome Chromosomal Region 22 Protein (WBSCR22) Antibody |
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| 20-abx142079 | Abbexa |
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Williams-Beuren Syndrome Chromosomal Region 22 Protein (WBSCR22) Antibody |
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| 20-abx005524 | Abbexa |
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Williams-Beuren Syndrome Chromosomal Region 22 Protein (WBSCR22) Antibody |
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| abx031474-400ul | Abbexa | 400 ul | EUR 627.6 |
Williams-Beuren Syndrome Chromosomal Region 22 Protein (WBSCR22) Antibody |
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| abx031474-80l | Abbexa | 80 µl | EUR 343.2 |
Williams-Beuren Syndrome Chromosomal Region 23 Protein (WBSCR23) Antibody |
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| abx037273-100ug | Abbexa | 100 ug | EUR 469.2 |
Williams-Beuren Syndrome Chromosomal Region 27 Protein (WBSCR27) Antibody |
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| abx025778-400ul | Abbexa | 400 ul | EUR 627.6 |
Williams-Beuren Syndrome Chromosomal Region 27 Protein (WBSCR27) Antibody |
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| abx025778-80l | Abbexa | 80 µl | EUR 343.2 |
Williams-Beuren Syndrome Chromosomal Region 11 Protein (WBSCR11) Antibody |
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| 20-abx215754 | Abbexa |
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Williams-Beuren Syndrome Chromosomal Region 27 Protein (WBSCR28) Antibody |
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| 20-abx307819 | Abbexa |
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Williams-Beuren Syndrome Chromosomal Region 27 Protein (WBSCR28) Antibody |
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| abx307819-100g | Abbexa | 100 µg | EUR 362.5 |
Williams-Beuren Syndrome Chromosomal Region 27 Protein (WBSCR28) Antibody |
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| abx307819-20g | Abbexa | 20 µg | EUR 162.5 |
Williams-Beuren Syndrome Chromosomal Region 27 Protein (WBSCR28) Antibody |
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| abx307819-50g | Abbexa | 50 µg | EUR 250 |
Williams-Beuren Syndrome Chromosomal Region 23 Protein (WBSCR23) Antibody |
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| abx037273-96tests | Abbexa | 96 tests | EUR 337.5 |
Williams-Beuren Syndrome Chromosomal Region 22 Protein (WBSCR22) Antibody |
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| abx031474-400l | Abbexa | 400 µl | EUR 518.75 |
Williams-Beuren Syndrome Chromosomal Region 27 Protein (WBSCR27) Antibody |
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| abx025778-400l | Abbexa | 400 µl | EUR 518.75 |
Williams-Beuren Syndrome Chromosomal Region 27 Protein (WBSCR27) Antibody |
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| abx240272-100l | Abbexa | 100 µl | Ask for price |
Williams-Beuren Syndrome Chromosomal Region 27 Protein (WBSCR27) Antibody |
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| abx240272-50l | Abbexa | 50 µl | EUR 350 |
Williams-Beuren Syndrome Chromosomal Region 22 Protein (WBSCR22) Antibody |
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| abx005524-100l | Abbexa | 100 µl | EUR 175 |
3`UTR clone of Williams-Beuren syndrome chromosome region 16 (WBSCR16) for miRNA target validation |
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| SC210586 | Origene Technologies GmbH | 10 µg | Ask for price |
Wbscr16 (Myc-DDK-tagged) - Mouse Williams-Beuren syndrome chromosome region 16 homolog (human) (Wbscr16) |
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| MR207363 | Origene Technologies GmbH | 10 µg | Ask for price |
WBSCR28 (Myc-DDK-tagged)-Human Williams-Beuren syndrome chromosome region 28 (WBSCR28) |
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| RC205458 | Origene Technologies GmbH | 10 µg | Ask for price |
WBSCR17 (Myc-DDK-tagged)-Human Williams-Beuren syndrome chromosome region 17 (WBSCR17) |
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| RC212796 | Origene Technologies GmbH | 10 µg | Ask for price |
Wbscr16 (untagged ORF) - Rat Williams-Beuren syndrome chromosome region 16 homolog (human) (Wbscr16), (10 ug) |
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| RN201834 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti-ORF clone of WBSCR16 (mGFP-tagged)-Human Williams-Beuren syndrome chromosome region 16 (WBSCR16) |
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| RC203234L4 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Human Williams-Beuren syndrome chromosome region 28 (WBSCR28), mGFP tagged |
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| RC205458L4 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Human Williams-Beuren syndrome chromosome region 17 (WBSCR17), mGFP tagged |
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| RC212796L2 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Human Williams-Beuren syndrome chromosome region 17 (WBSCR17), mGFP tagged |
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| RC212796L4 | Origene Technologies GmbH | 10 µg | Ask for price |
WBSCR16 (myc-DDK-tagged) - Human Williams-Beuren syndrome chromosome region 16 (WBSCR16), transcript variant 3 |
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| RC237704 | Origene Technologies GmbH | 10 µg | Ask for price |
WBSCR16 (myc-DDK-tagged) - Human Williams-Beuren syndrome chromosome region 16 (WBSCR16), transcript variant 2 |
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| RC238316 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti-ORF clone of WBSCR16 (Myc-DDK-tagged)-Human Williams-Beuren syndrome chromosome region 16 (WBSCR16) |
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| RC203234L3 | Origene Technologies GmbH | 10 µg | Ask for price |
Wbscr17 (untagged) - Mouse Williams-Beuren syndrome chromosome region 17 homolog (human) (Wbscr17), (10ug) |
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| MC219562 | Origene Technologies GmbH | 10 µg | Ask for price |
Dnajc30 (GFP-tagged) - Mouse Williams-Beuren syndrome chromosome region 18 homolog (human) (Wbscr18) |
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| MG202487 | Origene Technologies GmbH | 10 µg | Ask for price |
Recombinant Human Williams-Beuren syndrome chromosomal region 16 protein (WBSCR16) |
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| MBS1443917-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1330 |
Recombinant Human Williams-Beuren syndrome chromosomal region 16 protein (WBSCR16) |
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| MBS1443917-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1025 |
Recombinant Human Williams-Beuren syndrome chromosomal region 16 protein (WBSCR16) |
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| MBS1443917-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1125 |
Recombinant Human Williams-Beuren syndrome chromosomal region 16 protein (WBSCR16) |
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| MBS1443917-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1195 |
Recombinant Human Williams-Beuren syndrome chromosomal region 16 protein (WBSCR16) |
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| MBS1443917-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1280 |
Human Williams-Beuren syndrome chromosomal region 16 protein, WBSCR16 ELISA Kit |
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| MBS9340470-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6725 |
Human Williams-Beuren syndrome chromosomal region 16 protein, WBSCR16 ELISA Kit |
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| MBS9340470-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Human Williams-Beuren syndrome chromosomal region 16 protein, WBSCR16 ELISA Kit |
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| MBS9340470-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3420 |
Human Williams-Beuren syndrome chromosomal region 16 protein, WBSCR16 ELISA Kit |
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| MBS9340470-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
Mouse Williams-Beuren syndrome chromosomal region 16 protein (WBSCR16) ELISA Kit |
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| MBS282793-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6255 |
Mouse Williams-Beuren syndrome chromosomal region 16 protein (WBSCR16) ELISA Kit |
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| MBS282793-48StripWells | MyBiosource | 48-Strip-Wells | EUR 445 |
Mouse Williams-Beuren syndrome chromosomal region 16 protein (WBSCR16) ELISA Kit |
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| MBS282793-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3290 |
Mouse Williams-Beuren syndrome chromosomal region 16 protein (WBSCR16) ELISA Kit |
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| MBS282793-96StripWells | MyBiosource | 96-Strip-Wells | EUR 730 |
Wbscr16 (Myc-DDK-tagged ORF) - Rat Williams-Beuren syndrome chromosome region 16 homolog (human) (Wbscr16), (10 ug) |
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| RR201834 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Human Williams-Beuren syndrome chromosome region 28 (WBSCR28), Myc-DDK-tagged |
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| RC205458L3 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Human Williams-Beuren syndrome chromosome region 17 (WBSCR17), Myc-DDK-tagged |
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| RC212796L1 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Human Williams-Beuren syndrome chromosome region 17 (WBSCR17), Myc-DDK-tagged |
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| RC212796L3 | Origene Technologies GmbH | 10 µg | Ask for price |
3`UTR clone of Williams-Beuren syndrome chromosome region 17 (WBSCR17) for miRNA target validation |
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| SC214938 | Origene Technologies GmbH | 10 µg | Ask for price |
Lenti ORF clone of Wbscr16 (mGFP-tagged) - Mouse Williams-Beuren syndrome chromosome region 16 homolog (human) (Wbscr16) |
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| MR207363L4 | Origene Technologies GmbH | 10 µg | Ask for price |
Wbscr17 (Myc-DDK-tagged) - Mouse Williams-Beuren syndrome chromosome region 17 homolog (human) (Wbscr17) |
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| MR218409 | Origene Technologies GmbH | 10 µg | Ask for price |
Wbscr17 (GFP-tagged) - Mouse Williams-Beuren syndrome chromosome region 17 homolog (human) (Wbscr17), (10ug) |
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| MG218409 | Origene Technologies GmbH | 10 µg | Ask for price |
Wbscr17 (untagged ORF) - Rat Williams-Beuren syndrome chromosome region 17 homolog (human) (Wbscr17), (10 ug) |
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| RN214055 | Origene Technologies GmbH | 10 µg | Ask for price |
Mouse Williams-Beuren syndrome chromosomal region 16 protein homolog (RCC1L) ELISA Kit |
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| abx553340-96tests | Abbexa | 96 tests | EUR 687.5 |
Recombinant Mouse Williams-Beuren syndrome chromosomal region 16 protein homolog (Wbscr16) |
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| MBS1307117-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1330 |
Recombinant Mouse Williams-Beuren syndrome chromosomal region 16 protein homolog (Wbscr16) |
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| MBS1307117-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1020 |
Recombinant Mouse Williams-Beuren syndrome chromosomal region 16 protein homolog (Wbscr16) |
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| MBS1307117-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1125 |
Recombinant Mouse Williams-Beuren syndrome chromosomal region 16 protein homolog (Wbscr16) |
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| MBS1307117-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1190 |
Recombinant Mouse Williams-Beuren syndrome chromosomal region 16 protein homolog (Wbscr16) |
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| MBS1307117-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1280 |
Lenti ORF particles, WBSCR16 (mGFP-tagged)-Human Williams-Beuren syndrome chromosome region 16 (WBSCR16), 200ul, >10^7 TU/mL |
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| RC203234L4V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF clone of Wbscr16 (Myc-DDK-tagged) - Mouse Williams-Beuren syndrome chromosome region 16 homolog (human) (Wbscr16) |
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| MR207363L3 | Origene Technologies GmbH | 10 µg | Ask for price |
Wbscr28 (untagged) - Mouse Williams-Beuren syndrome chromosome region 28 (human) (Wbscr28), transcript variant 2, (10ug) |
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| MC211757 | Origene Technologies GmbH | 10 µg | Ask for price |
Wbscr28 (untagged) - Mouse Williams-Beuren syndrome chromosome region 28 (human) (Wbscr28), transcript variant 1, (10ug) |
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| MC211758 | Origene Technologies GmbH | 10 µg | Ask for price |
WBSCR27, NT (WBSCR27, Williams-Beuren syndrome chromosomal region 27 protein) |
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| MBS649488-02mL | MyBiosource | 0.2mL | EUR 695 |
WBSCR27, NT (WBSCR27, Williams-Beuren syndrome chromosomal region 27 protein) |
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| MBS649488-5x02mL | MyBiosource | 5x0.2mL | EUR 2975 |
Lenti ORF particles, WBSCR16 (Myc-DDK-tagged)-Human Williams-Beuren syndrome chromosome region 16 (WBSCR16), 200ul, >10^7 TU/mL |
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| RC203234L3V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF clone of Wbscr16 (mGFP-tagged ORF) - Rat Williams-Beuren syndrome chromosome region 16 homolog (human) (Wbscr16), (10 ug) |
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| RR201834L4 | Origene Technologies GmbH | 10 µg | Ask for price |
Wbscr17 (Myc-DDK-tagged ORF) - Rat Williams-Beuren syndrome chromosome region 17 homolog (human) (Wbscr17), (10 ug) |
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| RR214055 | Origene Technologies GmbH | 10 µg | Ask for price |
Mouse Williams-Beuren syndrome chromosomal region 14 protein (MLXIPL) ELISA Kit |
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| EK9543 | SAB | 96Т | EUR 799 |
Mouse Williams-Beuren syndrome chromosomal region 14 protein (MLXIPL) ELISA Kit |
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| AE33354MO-48Tests | Abebio | 48 Tests | EUR 325 |
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Description: Mouse (Mus musculus) |
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Mouse Williams-Beuren syndrome chromosomal region 14 protein (MLXIPL) ELISA Kit |
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| AE33354MO-96Tests | Abebio | 96 Tests | EUR 610 |
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Description: Mouse (Mus musculus) |
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Moreover, we additionally recognized two medication, particularly pidorubicine, a topoisomerase inhibitor (LINCS ID- BRD-Okay04548931) and Polo-like kinase inhibitor (LINCS ID- BRD-Okay41652870) having the validated position in reversing the differential gene expression patterns noticed within the three GSE datasets used. Collectively, this examine aids within the understanding of the molecular drivers, vital genes and pathways that underlie DKD initiation and development.
